β_(1)肾上腺素能受体Arg389Gly基因多态性与心肌梗死后心室重构的关系  

Relationship between β_(1)-adrenoceptor Arg389Gly gene polymorphism with ventricular remodeling after myocardial infarction

作　　者：李俊萍[1] 郭晓华[1] 陈强[1] LI Junping;GUO Xiaohua;CHEN Qiang(Department of Cardiology,the First Hospital Affiliated Baotou Medical College,Baotou,Inner Mongolia,014010,China)

机构地区：[1]包头医学院第一附属医院心内科,内蒙古包头014010

出　　处：《当代医学》2023年第20期98-103,共6页Contemporary Medicine

基　　金：包头市卫生基金科研项目(2014S2003-5-4)。

摘　　要：目的探讨β_(1)肾上腺素能受体(β_(1)-AR)Arg389Gly基因多态性与心肌梗死后心室重构的关系。方法选取2014年1月至2015年12月本院收治的120例ST段抬高心肌梗死患者作为研究对象,采用聚合酶链式反应-限制性酶片段长度多态性(PCR-RFLP)技术检测患者β_(1)-ARArg389Gly多态性位点基因型,采用超声心动图测量左心室舒张末期内径(LVDD)及左心室射血分数(LVEF)。分析β_(1)-ARArg389Gly多态性基因型频率分布,比较不同β_(1)-ARArg389Gly基因型患者一般情况及LVDD、LVEF。结果Arg389纯合子患者与Gly389等位基因携带患者年龄、性别、吸烟、高血压、糖尿病、前壁心肌梗死、梗死相关血管开通比例及总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)水平比较差异无统计学意义。梗死后1周,Arg389纯合子患者与Gly389等位基因携带患者LVDD、LVEF比较差异无统计学意义;梗死后6个月,Arg389纯合子患者与Gly389等位基因携带患者LVDD均长于梗死后1周,LVEF均低于梗死后1周,但Arg389纯合子患者LVDD短于Gly389等位基因携带患者,LVEF高于Gly389等位基因携带患者,差异有统计学意义(P<0.05)。结论β_(1)-AR Arg389Gly基因多态性与心肌梗死后左心室重构有关,临床应及早给予患者再灌注治疗、开通梗死相关血管,以改善患者预后。Objective To investigate the relationship betweenβ_(1)-adrenoceptor(β_(1)-AR)Arg389Gly gene polymorphism with ventricular remodel-ing after myocardial infarction.Methods 120 patients with acute ST-segment elevated myocardial infarction admitted to our hospital from January 2014 to December 2015 were selected as the research subjects,polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP)was used to detect the genotype ofβ_(1)-AR Arg389Gly polymorphic loci,echocardiograms were used to measure left ventricular end-diastolic diameter(LVDD)and left ventricular ejection fraction(LVEF).The frequency distribution ofβ_(1)-AR Arg389Gly polymorphic genotype was analyzed,and the general situation,LVDD and LVEF of patients with differentβ_(1)-AR Arg389Gly genotypes carriers were compared.Results There were no significant difference in the proportion of age,sex,smoking,hypertension,diabetes,anterior myocardial infarction,infarct-related vascular opening ratio,and the levels of total cholesterol(TC),triglyceride(TG),high-density lipoprotein cholesterol(HDL-C),and low-density lipoprotein cholesterol(LDL-C)be-tween the Arg389 homozygous patients and Gly389 allele-carrier patients.There were no significant differences in LVDD and LVEF between Arg389 homozygous patients and Gly389 allele-carrier patients;6 months after infarction,LVDD in Arg389 homozygous patients and Gly389 allele-carrier pa-tients was longer than that 1 week after infarction,and LVEF was lower than that 1 week after infarction,but LVDD in Arg389 homozygous patients was shorter than that in Gly389 allele-carrier patients,and LVEF was higher than that in Gly389 allele-carrier patients,the differences were statistically significant(P<0.05).Conclusionβ_(1)-AR Arg389Gly gene polymorphism is associated with left ventricular remodeling after myocardial infarction,and reperfusion therapy should be given to patients as early as possible to open infarct-related vessels to improve the prognosis of patients.

关 键 词：β_(1)肾上腺素能受体 基因多态性 心室重构 

分 类 号：R542.22[医药卫生—心血管疾病]