托拉塞米和呋塞米治疗心功能不全的临床疗效比较  

Comparison of clinical efficacy of torasemide and furosemide in the treatment of cardiac insufficiency

作　　者：吴海松[1] 刘欣卉 杨东妮[1] WU Haisong;LIU Xinhui;YANG Dongni(Department of Cardiology,Shenyang Red Cross Hospital,Shenyang,Liaoning,110013,China;Liaoning University of Traditional Chinese Medicine,Shenyang,Liaoning,110847,China)

机构地区：[1]沈阳市红十字会医院心内科,辽宁沈阳110013 [2]辽宁中医药大学,辽宁沈阳110847

出　　处：《当代医学》2023年第22期17-20,共4页Contemporary Medicine

基　　金：沈阳市科学技术计划项目(19-110-4-28)。

摘　　要：目的比较托拉塞米和呋塞米治疗心功能不全的临床疗效。方法选取2019年7月至2020年12月本院收治的80例心功能不全患者作为研究对象,随机分为对照组与实验组,各40例。对照组采用呋塞米治疗,实验组采用托拉塞米治疗,比较两组临床疗效、安全性、血钾水平、尿量、体质量、心功能指标。结果实验组治疗总有效率为92.50%,高于对照组的75.00%,差异有统计学意义(P<0.05);实验组不良反应发生率为2.50%,低于对照组的15.00%,差异有统计学意义(P<0.05)。治疗后,两组血钾水平、体质量低于治疗前,尿量多于治疗前,且实验组血钾水平、体质量低于对照组,尿量多于对照组,差异有统计学意义(P<0.05)。治疗后,两组左心室射血分数(LVEF)高于治疗前,左心室舒张末期内径(LVEDD)、左心室收缩末期内径(LVESD)均短于治疗前,且实验组LVEF高于对照组,LVEDD、LVESD短于对照组,差异有统计学意义(P<0.05)。治疗后,两组血管内皮细胞黏附分子-1(VCAM-1)、可溶性细胞间黏附分子-1(ICAM-1)均低于治疗前,且实验组低于对照组,差异有统计学意义(P<0.05)。结论拉托塞米治疗心功能不全效果确切,具有利尿效果显著,可明显改善患者心功能,且安全性较高,值得临床推广应用。Objective To compare the clinical efficacy of torasemide and furosemide in the treatment of cardiac insufficiency.Methods A total of 80 patients with cardiac insufficiency admitted to our hospital from July 2019 to December 2020 were selected as the research subjects,and they were randomly divided into the control group and the experimental group,with 40 cases in each group.The control group was treated with furose-mide,and the experimental group was treated with torasemide.The clinical efficacy,safety,blood potassium level,urine volume,body mass and car-diac function indexes were compared between the two groups.Results The total effective rate in the experimental group was 92.50%,which was higher than 75.00%in the control group,the difference was statistically significant(P<0.05).The incidence of adverse reactions in the experimental group was 2.50%,which was lower than 15.00%in the control group,and the difference was statistically significant(P<0.05).After treatment,the blood potassium level and body mass of the two groups were lower than before treatment,and the urine volume was higher than before treatment,and the blood potassium level and body mass in the experimental group were lower than that in the control group,and the urine volume was higher than that of the control group,the differences were statistically significant(P<0.05).After treatment,the left ventricular ejection fraction(LVEF)of the two groups was higher than that before treatment,and the left ventricular end diastolic diameter(LVEDD)and left ventricular end-systolic dimension(LVESD)were lower than before treatment,and LVEF in the experimental group was higher than that in the control group,LVEDD and LVESD were lower than those in the control group,the differences were statistically significant(P<0.05).After treatment,human vascular cell adhesion molecule 1(VCAM-1),intercellular cell adhesion molecule-1(ICAM-1)were lower than before treatment,and the experimental group was lower than the con-trol group,the differences were statistically signif

关 键 词：心功能不全 托拉塞米 呋塞米 血钾 尿量 心功能 

分 类 号：R541[医药卫生—心血管疾病]