主观认知下降患者的静息态功能磁共振低频振幅变化  

Changes in amplitude of low-frequency fluctuation of functional magnetic resonance imaging in subjective cognitive decline

作　　者：丁洪园 张玲[1] 唐银 王彤 朱奕 吴婷[4] 祁鸣[1] DING Hongyuan;ZHANG Ling;TANG Yin;WANG Tong;ZHU Yi;WU Ting;QI Ming(Department of Radiology,The First Affiliated Hospital of Nanjing Medical University,Nanjing 210029,China;Department of Radiology,Jingjiang People's Hospital,Taizhou 214500,China;Rehabilitation Center,The First Affiliated Hospital of Nanjing Medical University,Nanjing 210029,China;Department of Neurology,The First Affiliated Hospital of Nanjing Medical University,Nanjing 210029,China)

机构地区：[1]南京医科大学第一附属医院放射科,江苏南京210029 [2]靖江市人民医院放射科,江苏泰州214500 [3]南京医科大学第一附属医院康复医学中心,江苏南京210029 [4]南京医科大学第一附属医院神经内科,江苏南京210029

出　　处：《分子影像学杂志》2023年第5期787-791,共5页Journal of Molecular Imaging

基　　金：国家重点研发计划(2018YFC2001600、2018YFC2001603)。

摘　　要：目的探究低频振幅(ALFF)在主观认知下降(SCD)患者中的改变及其与临床认知量表的相关性,为延缓和预防阿尔茨海默病的进展赢得宝贵时间窗。方法共招募45例SCD患者和40例匹配良好的健康对照组,最终纳入ALFF值分析的分别为35例和33例。所有受试者均进行静息态磁共振脑功能成像扫描和相关临床量表评估。采用ALFF分析方法比较两组间ALFF值存在差异的脑区,采用线性回归分析评估所有受试者各脑区ALFF值与临床认知评估量表之间的相关性。结果与健康对照组相比,SCD组左侧枕上回、左侧顶上回、左侧楔叶和楔前叶、左小脑以及右侧罗兰氏岛盖部的ALFF值均较低,差异有统计学意义(P<0.05)。SCD患者右侧罗兰氏岛盖部的ALFF值与韦氏逻辑记忆测试和波士顿命名测试评分呈正相关关系;左侧枕上回ALFF值与波士顿命名测试评分呈正相关关系,与连线测试A评分呈负相关关系(P<0.05)。结论SCD患者有异常的脑活动信号,且异常脑区的ALFF值与部分临床量表评估具有相关性,ALFF可能被认为是早期发现这些患者的特征性生物标志物。Objective To investigate the changes in amplitude of low-frequency(ALFF)and the correlations between ALFF and clinical cognitive evaluations in subjective cognitive decline(SCD)patients,in order to gain a valuable time window for delaying and preventing the progress of Alzheimer's disease.Methods Forty-five patients with SCD(SCD group)and forty well-matched healthy controls(healthy control group)were recruited in this study,thirty-five and thirth-three case were included in ALFF value analysis,respectively.All subjects were examined by functional MRI and assessed with multiple clinical scales.The changes of brain area between SCD and healthy control group were compared by ALFF analysis method.In addition,linear regression analysis was used to evaluate the correlation between ALFF values and clinical scores of all subjects.Results The ALFF values of the left superior occipital gyrus,left superior parietal gyrus,left cuneus and precuneus,left cerebellum and right Rolandic operculum were lower in the SCD group compared with healthy control group,the difference was statistically significant(P<0.05).Among the SCD patients,the ALFF values of right Rolandic operculum were positively correlated with the Wechsler logical memory test and Boston naming test scores.The Boston naming test scores were also positively correlated with the ALFF values of left superior occipital gyrus.Additionally,the ALFF values of left superior occipital gyrus showed a significant negative correlation with trail making test A scores(P<0.05).Conclusion SCD patients have abnormal brain activity signals,and the ALFF values of abnormal brain regions are correlated with some clinical scale evaluations.ALFF may be considered as a characteristic biomarker for early detection of these patients.

关 键 词：主观认知下降 静息态磁共振脑功能成像 低频振幅 阿尔茨海默病 

分 类 号：R445.2[医药卫生—影像医学与核医学] R749.1[医药卫生—诊断学]