甘精胰岛素联合利拉鲁肽对2型糖尿病患者胰岛β细胞功能及脂代谢的影响研究  

Study on the Effect of Insulin Glargine Combined with Liraglutide on Pancreatic Beta Cell Function and Lipid Metabolism in Patients with Type 2 Diabetes

作　　者：刘凡 周述娜 LIU Fan;ZHOU Shuna(Department of Internal Medicine,Zhanlan Road Hospital,Xicheng District,Beijing 100044 China;Rehabilitation Department,Zhanlan Road Hospital,Xicheng District,Beijing 100044 China)

机构地区：[1]北京市西城区展览路医院内科,北京100044 [2]北京市西城区展览路医院康复科,北京100044

出　　处：《糖尿病新世界》2023年第16期31-34,38,共5页Diabetes New World Magazine

摘　　要：目的 探究甘精胰岛素联合利拉鲁肽对2型糖尿病患者胰岛β细胞功能及脂代谢的影响。方法 选取2021年6月—2022年12月于北京市西城区展览路医院就医的80例2型糖尿病患者为研究对象,根据随机数表法分为对照组和观察组,各40例。对照组采用甘精胰岛素进行治疗,观察组则采用甘精胰岛素联合利拉鲁肽进行治疗。比较两组治疗前后的血糖检测指标、胰岛功能指标[胰岛素抵抗指数(homeostatic model assessment of insulin resistance index,HOMA-IR)及胰岛β细胞功能指数(homeostatic model assessment of β-cell function,HOMA-β)]及脂代谢相关指标。结果 治疗前,两组的血糖检测指标、胰岛β细胞功能指标及脂代谢相关指标比较,差异无统计学意义(P>0.05)。治疗3个月后,观察组的血糖检测指标、HOMA-IR、瘦素及血脂指标显著低于对照组,血清脂联素及HOMA-β显著高于对照组,且两组的检测结果显著优于治疗前,差异有统计学意义(P<0.05)。结论 甘精胰岛素联合利拉鲁肽对2型糖尿病患者中的应用效果较好,且可显著改善胰岛β细胞功能及脂代谢状态,因此在2型糖尿病患者中的应用价值较高。Objective To explore the effect of insulin glargine combined with liraglutide on islet β-cell function and lipid metabolism in patients with type 2 diabetes mellitus.Methods A total of 80 patients with type 2 diabetes who were treated in Exhibition Road Hospital,Xicheng District,Beijing from June 2021 to December 2022 were selected as the study objects,and were divided into control group and observation group according to random number table method,with 40 patients in each group.The control group was treated with insulin glargine,and the observation group was treated with insulin glargine combined with liraglutide.Blood glucose detection indexes and islet function indexes before and after treatment were compared between the two groups [homeostatic model assessment of insulin resistance index,(homeostatic model assessment of insulin resistance index,HOMA-IR),homeostatic model assessment of β-cell function(HOMA-β)] and related indexes of lipid metabolism.Results Before treatment,there was no statistically significant difference in blood glucose detection indexes,islet β cell function indexes and lipid metabolism related indexes between the two groups(P>0.05).After 3 months of treatment,blood glucose detection indexes,HOMAIR,leptin and blood lipid indexes in the observation group were significantly lower than those in the control group,and serum adiponectin and HOMA-β were significantly higher than those in the control group,and the detection results of the two groups were significantly better than those before treatment,and the difference was statistically significant(P<0.05).Conclusion Insulin glargine combined with liraglutide has a good effect on the application of type 2 diabetes patients,and can significantly improve the function of pancreatic β cells and lipid metabolism,so it has a high application value in type 2 diabetes patients.

关 键 词：甘精胰岛素 利拉鲁肽 2型糖尿病 血糖 胰岛Β细胞功能 脂代谢 

分 类 号：R587[医药卫生—内分泌]