玻璃体腔注射雷珠单抗治疗糖尿病视网膜病变的临床疗效  

Clinical Effect of Intravitreal Injection of Leizumab in the Treatment of Diabetic Retinopathy

作　　者：洪晓东 苏志强 陈丽娟[2] 王志平 林纪阳 HONG Xiaodong;SU Zhiqiang;CHEN Lijuan;WANG Zhiping;LIN Jiyang(Department of Ophthalmology,the Second Hospital of Zhangzhou,Zhangzhou,Fujian Province,363199 China;Zhangzhou Vocational College of Health,Zhangzhou,Fujian Province,363199 China)

机构地区：[1]漳州市第二医院眼科,福建漳州363199 [2]漳州卫生职业学院,福建漳州363199

出　　处：《糖尿病新世界》2023年第16期68-71,共4页Diabetes New World Magazine

基　　金：福建省中青年教师教育科研项目(JAT210866);漳州卫生职业学院院级科研项目(ZWYZ202103)。

摘　　要：目的 评估玻璃体腔注射雷珠单抗(intravitreal injection of leizumab,IVR)应用在糖尿病视网膜病变(diabetic retinopathy,DR)患者中的临床疗效。方法 选取2019年1月—2022年12月漳州市第二医院眼科的150例DR患者为研究对象,参照随机数字表法分为对照组(纳入75例,采用常规药物治疗)、观察组(纳入75例,加用IVR),比较两组临床有效率、最佳矫正视力(best corrected vision,BCVA)、黄斑中心凹视网膜厚度(macular foveal retinal thickness,CMT)、视网膜厚度、低视力者生活质量量表中文版(Low Vision Quality of Life Scale Chinese version,CLVQOL)、恢复时间、并发症。结果 相较对照组,观察组临床有效率更高,恢复时间更短,并发症更少,差异有统计学意义(P<0.05);治疗前,两组BCVA、CMT、视网膜厚度、CLVQOL比较,差异无统计学意义(P>0.05);治疗3个月后,相较对照组,观察组BCVA、CLVQOL更高,CMT、视网膜厚度更低,差异有统计学意义(P<0.05)。结论 对DR患者实施IVR,可以增强疗效,减少CMT及视网膜厚度,改善视力、生活质量,降低并发症发生风险,加快康复进程,值得推广。Objective To evaluate the clinical efficacy of Intravitreal injection of leizumab(IVR) in patients with Diabetic retinopathy(DR).Methods 150 DR patients from the Ophthalmology Department of Zhangzhou Second Hospital from January 2019 to December 2022 were selected as the study subjects.They were randomly divided into a control group(75 cases included,treated with conventional drugs) and an observation group(75 cases included,treated with IVR) using a random number table method.The clinical efficacy,best corrected vision(BCVA),macular foveal retinal thickness(CMT),retinal thickness Low Vision Quality of Life Scale Chinese version(CLVQOL),recovery time,and complications were compared between the two groups.Results Compared with the control group,the observation group had a higher clinical effective rate,shorter recovery time,and fewer complications,the difference was statistically significant(P<0.05);Before treatment,there was no statistically significant difference in BCVA,CMT,retinal thickness,and CLVQOL between the two groups(P>0.05);After 3 months of treatment,compared to the control group,the observation group had higher BCVA and CLVQOL,lower CMT and retinal thickness,and the difference was statistically significant(P<0.05).Conclusion IVR for DR patients can enhance the efficacy,reduce CMT and retinal thickness,improve vision,quality of life,reduce the risk of complications,and accelerate the rehabilitation process,which is worth promoting.

关 键 词：玻璃体腔注射雷珠单抗 糖尿病视网膜病变 最佳矫正视力 黄斑中心凹视网膜厚度 

分 类 号：R4[医药卫生—临床医学]