阿卡波糖联合盐酸二甲双胍治疗2型糖尿病疗效及不良反应发生率的分析  

Analysis of Curative Effect and Incidence of Adverse Reactions of Acarbose Combined with Metformin Hydrochloride in the Treatment of Type 2 Diabetes Mellitus

作　　者：李霞[1] 林燕[1] 吴梅花[1] 林琳[1] LI Xia;LIN Yan;WU Meihua;LIN Lin(Western Pharmacy,Affiliated People's Hospital of Fujian University of Traditional Chinese Medicine,Fuzhou,Fujian Province,350004 China)

机构地区：[1]福建中医药大学附属人民医院西药房,福建福州350004

出　　处：《糖尿病新世界》2023年第16期80-83,共4页Diabetes New World Magazine

摘　　要：目的 分析在2型糖尿病患者的治疗中联合应用阿卡波糖及盐酸二甲双胍的疗效及不良反应。方法回顾性分析2021年4月—2022年3月福州市晋安区医院收治的102例2型糖尿病患者的临床资料,依照随机数表法分组,将采用二甲双胍治疗的51例患者设为对照组,采用二甲双胍+阿卡波糖治疗的51例患者设为研究组。对比两组的不良反应发生率及治疗前后的胰岛素细胞功能指标、血糖指标。结果 治疗后研究组餐后2 h血糖、糖化血红蛋白、空腹血糖低于对照组,差异有统计学意义(P<0.05)。治疗后研究组的胰岛素抵抗指数低于对照组,胰岛素分泌指数高于对照组,差异有统计学意义(P<0.05)。对照组的不良反应发生率(1.96%)低于研究组(5.88%),但差异无统计学意义(P>0.05)。结论 阿卡波糖联合盐酸二甲双胍对2型糖尿病有显著疗效和安全性,对患者胰岛功能和血糖水平有显著改善作用。Objective To analyze the efficacy and adverse reactions of combined application of acarbose and metformin hydrochloride in the treatment of patients with type 2 diabetes mellitus.Methods The clinical data of 102 patients with type 2 diabetes admitted to Fuzhou Jin'an District Hospital from April 2021 to March 2022 were retrospectively analyzed.According to the method of random number table,51 patients treated with metformin were set as the control group,and 51 patients treated with metformin+acarbose were set as the study group.Compared the incidence of adverse reactions,insulin cell function indicators,and blood glucose indicators before and after treatment between the two groups.Results After treatment,the 2-hour postprandial blood glucose,glycated hemoglobin,and fasting blood glucose in the study group were lower than those in the control group,the difference was statistically significant(P<0.05).After treatment,the insulin resistance index of the study group was lower than that of the control group,and the insulin secretion index was higher than that of the control group,the difference was statistically significant(P<0.05).The incidence of adverse reactions in the control group(1.96%) was lower than that in the study group(5.88%),but the difference was not statistically significant(P>0.05).Conclusion Acarbose combined with metformin hydrochloride has significant efficacy and safety in the treatment of type 2 diabetes,and can significantly improve pancreatic islet function and blood glucose levels in patients.

关 键 词：阿卡波糖 盐酸二甲双胍 2型糖尿病 疗效 不良反应 

分 类 号：R587.1[医药卫生—内分泌]