速效胰岛素类似物诺和锐治疗初诊妊娠糖尿病的临床效果分析  

Analysis of the Clinical Efficacy of the Rapid-acting Insulin Analog NovoRapid in the Treatment of Newly Diagnosed Gestational Diabetes

作　　者：谢佩真 卓秋莺 陈伟 XIE Peizhen;ZHUO Qiuying;CHEN Wei(Department of Obstetrics,Affiliated Hospital of Putian University,Putian,Fujian Province,351100 China)

机构地区：[1]莆田学院附属医院产科,福建莆田351100

出　　处：《糖尿病新世界》2023年第16期95-97,101,共4页Diabetes New World Magazine

摘　　要：目的 探讨对初诊妊娠糖尿病患者采用速效胰岛素类似物诺和锐完成治疗后获得的临床效果。方法选取2019年11月—2021年12月莆田学院附属医院初诊妊娠糖尿病患者77例为研究对象,采用随机数表法分组,参照组38例采用诺和灵R进行治疗,研究组39例采用速效胰岛素类似物诺和锐进行治疗。比较两组患者不良妊娠结局(新生儿低血糖、羊水过多、早产、胎儿宫内窘迫、巨大胎儿)总发生率以及血糖达标所需时间,糖化血红蛋白、空腹血糖以及餐后2 h血糖水平。结果 研究组不良妊娠结局(新生儿低血糖、羊水过多、早产、胎儿宫内窘迫、巨大胎儿)总发生率低于参照组,差异有统计学意义(P<0.05);研究组血糖达标所需时间较参照组更短,差异有统计学意义(P<0.05);治疗前,研究组糖化血红蛋白、空腹血糖以及餐后2 h血糖水平与参照组比较,差异无统计学意义(P>0.05);治疗后,研究组糖化血红蛋白、空腹血糖以及餐后2 h血糖水平低于参照组,差异有统计学意义(P<0.05)。结论 速效胰岛素类似物诺和锐较诺和灵R治疗初诊妊娠糖尿病患者的效果更优,可显著改善患者的不良妊娠结局,有效缩短患者血糖达标所需时间,显著降低患者糖化血红蛋白、空腹血糖以及餐后2 h血糖水平,促进初诊妊娠糖尿病患者良好预后。Objective To explore the clinical effect of newly diagnosed gestational diabetes mellitus patients after treatment with rapid-acting insulin analogue NovoRapid.Methods From November 2019 to December 2021,77 patients with gestational diabetes who were initially diagnosed in the Affiliated Hospital of Putian University were selected as the study subjects,The random number table method was used to group,the reference group of 38 patients treated with NovoRapid and research group of 39 patients treated with the fast-acting insulin analogue NovoRapid.The overall incidence of adverse pregnancy outcomes(neonatal hypoglycemia,polyhydramnios,premature birth,fetal intrauterine distress,fetal macrosomia) and the time required for blood glucose to reach target,glycosylated hemoglobin,fasting blood glucose,and 2-hour postprandial blood glucose levels were compared between the two groups.Results The total incidence of adverse pregnancy outcomes(neonatal hypoglycemia,polyhydramnios,premature birth,fetal intrauterine distress,fetal macrosomia) in the study group was lower than that in the control group,and the difference was statistically significant(P<0.05).The time required for blood glucose to reach the standard in the study group was shorter than that in the reference group,and the difference was statistically significant(P<0.05).Before treatment,there was no statistically significant difference in the levels of glycated hemoglobin,fasting blood glucose,and 2-hour postprandial blood glucose between the study group and the reference group(P>0.05);after treatment,the levels of glycated hemoglobin,fasting blood glucose,and 2-hour postprandial blood glucose in the study group were significantly lower than those in the control group,and the difference was statistically significant(P<0.05).Conclusion The rapid-acting insulin analogue NovoRapid is more effective than NovoRapid in the treatment of patients with newly diagnosed gestational diabetes mellitus.It can significantly improve the adverse pregnancy outcomes of patients and e

关 键 词：速效胰岛素类似物诺和锐 初诊妊娠糖尿病 治疗效果 

分 类 号：R47[医药卫生—护理学]