Hcy、FPG、HbA1c、UAlb水平与糖尿病足严重程度的相关性  

Correlation between Hcy,FPG,HbA1c,UAlb Levels and the Severity of Diabetic Foot

作　　者：倪倩 刘小娜 王伟 NI Qian;LIU Xiaona;WANG Wei(Department of Laboratory Medicine,Yancheng First People's Hospital,Yancheng,Jiangsu Province,224000 China)

机构地区：[1]盐城市第一人民医院检验科,江苏盐城224000

出　　处：《糖尿病新世界》2023年第16期182-184,198,共4页Diabetes New World Magazine

摘　　要：目的 分析糖尿病足严重程度与血浆同型半胱氨酸(homocysteine,Hcy)、空腹血糖(fasting plasma glucose,FPG)、糖化血红蛋白(glycosylated hemoglobin,HbA1c)、尿微量白蛋白(urinary microalbumin,UAlb)的相关性。方法 选取2020年1月—2023年3月盐城市第一人民医院检验科收治的60例糖尿病患者为研究对象,依据有无并发糖尿病足分成两组,将并发糖尿病足的患者纳入研究组(21例),未并发糖尿病足患者纳入对照组(39例),检测并对比两组血浆Hcy、FPG、HbA1c与UAlb水平,对比各分级患者(Wagner分级标准)的血浆Hcy、FPG、HbA1c与UAlb水平,并分析此类指标与糖尿病足病变程度间的相关性(Spearman相关分析)。结果 研究组血浆Hcy、FPG、HbA1c与UAlb水平均较对照组高,差异有统计学意义(P<0.05)。研究组中,血浆Hcy、FPG、HbA1c、UAlb水平均伴随Wagner分级的增加而随之升高,不同Wagner分级患者的血浆Hcy、FPG、HbA1c、UAlb水平对比,差异有统计学意义(P<0.05)。经Spearman分析得知,血浆Hcy、FPG、HbA1c、UAlb与糖尿病足病情之间存在紧密相关性(P<0.05)。结论 Hcy、FPG、HbA1c、UAlb水平与糖尿病足病情程度之间存在紧密联系,通过检测此类指标,可提高诊断效能。Objective To analyze the correlation between the severity of diabetic foot and plasma homocysteine(Hcy),fasting plasma glucose(FPG),glycated hemoglobin(HbA1c),and urinary microalbumin(UAlb) for joint testing.Methods 60 patients with diabetes admitted to the clinical laboratory of Yancheng First People's Hospital from January 2020 to March 2023 were selected as the study objects,and divided into two groups according to whether they had diabetic foot or not.Patients with diabetic foot complications were included in the study group(21 cases),and patients without diabetic foot complications were included in the control group(39 cases).The plasma levels of Hcy,FPG,HbA1c and UAlb in the two groups were detected and compared,and the plasma levels of Hcy,FPG,HbA1c and UAlb in patients with different grades(Wagner grading criteria) were compared,and the correlation between these indexes and the degree of diabetic foot lesions was analyzed(Spearman correlation analysis).Results The plasma levels of Hcy,FPG,HbA1c and UAlb in the study group were higher than those in the control group,and the difference was statistically significant(P<0.05).In the study group,the plasma levels of Hcy,FPG,HbA1c and UAlb all increased with the increase of Wagner grade,and the plasma levels of Hcy,FPG,HbA1c and UAlb of patients with different Wagner grades were compared,and the difference was statistically significant(P<0.05).Spearman analysis showed that plasma Hcy,FPG,HbA1c,UAlb were closely correlated with diabetic foot disease(P<0.05).Conclusion The level of Hcy,FPG,HbA1c,UAlb is closely related to the degree of diabetic foot disease,and the diagnostic efficiency can be improved by detecting these indicators.

关 键 词：糖尿病足 同型半胱氨酸 空腹血糖 糖化血红蛋白 尿微量白蛋白 

分 类 号：R4[医药卫生—临床医学]