卡因类非法添加物检测技术研究进展  

Research Progress on the Detection Technology of Caine-Type Illegal Additives

作　　者：周纯洁 程辉跃 ZHOU Chunjie;CHENG Huiyue(Chongqing Institute for Food and Drug Control·NMPA Key Laboratory for Quality Monitoring of Narcotic Drugs and Psychotropic Substances,Chongqing,China 401121)

机构地区：[1]重庆市食品药品检验检测研究院·国家药品监督管理局麻醉精神药品质量监测重点实验室,重庆401121

出　　处：《中国药业》2023年第19期1-6,共6页China Pharmaceuticals

基　　金：重庆市社会民生科技创新专项[cstc2016shms-zd00002]。

摘　　要：目的 优化卡因类非法添加物的检测方法,为日常监管提供更有效的技术支撑。方法 检索中国知网(CNKI)、万方(WanFang)、维普(VIP)、ScienceDirect等数据库中有关化妆品、畜产品、水产品中卡因类局部麻醉药检测技术的文献,检索时限为2018年1月11日至2023年7月2日,提取并分析不同检测技术在该领域应用的相关数据。结果 高效液相色谱法、高效液相色谱串联质谱法、气相色谱-质谱法在卡因类非法添加物检测中的应用较广泛,尤其是具有高灵敏度、高选择性和高分析通量的高效液相色谱串联质谱法是卡因类非法添加物检测的主要方法。各类快速检测方法可有效提高现场执法效率。结论 仪器分析技术及各类快速检测方法的不断发展可有效提高监管部门对卡因类非法添加问题的追踪效率和打击力度。Objective To optimize the detection methods for caine-type illegal additives,and to provide more effective technical support for daily supervision.Methods Studies related to the detection technology of caine-type local anesthesia drugs in cosmetics,livestock and aquatic products in databases such as CNKI,WanFang,VIP,and ScienceDirect from January 11,2018 to July 2,2023,and the relevant data of different detection technologies applied in this field were analyzed.Results High-performance liquid chromatography(HPLC),HPLC-tandem mass spectrometry(MS/MS),and gas chromatography-mass spectrometry(GC-MS) were widely used in the detection of caine-type illegal additives,especially the HPLC-MS/MS with high sensitivity,selectivity,and throughput was the main method for the detection of caine-type illegal additives.The fast detection technology in rapid development could improve the efficiency of on-site law enforcement.Conclusion The continuous development of instrument analysis technology and the fast detection technology can effectively improve the tracking efficiency and carckdown by regulatory authorities on caine-type illegal additives.

关 键 词：卡因类局部麻醉药 非法添加 高效液相色谱法 高效液相色谱串联质谱法 气相色谱-质谱法 

分 类 号：R927.1[医药卫生—药学] R971