临床药师促进胃肠外科抗菌药物合理应用的实践  

Clinical Pharmacists′ Participation in Promoting the Rational Application of Antibiotics in Gastrointestinal Surgery

作　　者：张梨 郑冬妮[1] 任常谕 龙霞[1] 张琪敏 周后凤[1] ZHANG Li;ZHENG Dongni;REN Changyu;LONG Xia;ZHANG Qimin;ZHOU Houfeng(Chengdu Fifth People's Hospital,Chengdu,Sichuan,China 611130;Department of Pharmacy,Southwest Medical University,Luzhou,Sichuan,China 646000)

机构地区：[1]四川省成都市第五人民医院,四川成都611130 [2]西南医科大学药学院,四川泸州646000

出　　处：《中国药业》2023年第19期46-49,共4页China Pharmaceuticals

基　　金：四川省成都市卫生健康委员会医学科研课题项目[2022435]。

摘　　要：目的 总结某院胃肠外科实施临床药师主导的抗菌药物管理模式的经验与成效。方法 建立抗菌药物使用路线图,以药学干预方式保证其实施,分析干预前后抗菌药物的使用强度、使用品种占比及处方点评不合理使用情况。结果 干预后,胃肠外科抗菌药物使用强度降幅为9.02%;第3代头孢菌素类抗菌药物使用量(累计DDD数)由59.50升至1 360.59,β内酰胺类抗菌药物/β内酰胺酶抑制剂使用量(累计DDD数)7 848.63降至5 825.34;预防性不合理使用抗菌药物占比从干预前的6.50%降至1.50%(P <0.05),治疗性使用抗菌药物不合理占比从干预前的12.00%降至2.00%(P <0.01)。结论 临床药师主导的抗菌药物管理模式有效提高了胃肠外科抗菌药物的使用合理性。Objective To summarize the experience and effectiveness of the clinical pharmacist-led antibiotics management model in the Gastrointestinal Surgery of a hospital.Methods Route diagrams for antibiotics use were established,and implemented by pharmaceutical intervention.Antibiotic use density(AUD),proportion of antibiotics types and irrational drug use in prescription review were analyzed before and after the intervention.Results After the intervention,the AUD in the Gastrointestinal Surgery decreased by 9.02%;the consumption of antibiotics(cumulative DDD) of third-generation cephalosporins increased from 59.50to 1 360.59,and the consumption of β-lactam/β-lactamase inhibitors(cumulative DDD) decreased from 7 848.63 to 5 825.34;the proportion of irrational use of prophylactic antibiotics decreased from 6.50% to 1.50%(P<0.05),and the proportion of irrational use of therapeutic antibiotics decreased from 12.00% to 2.00%(P<0.01).Conclusion The clinical pharmacist-led antibiotics management model effectively improves the rational use of antibiotics in the Gastrointestinal Surgery.

关 键 词：临床药师 抗菌药物 胃肠外科 腹腔感染 合理用药 

分 类 号：R969.3[医药卫生—药理学] R978.1[医药卫生—药学]