阿魏酸钠治疗早期糖尿病肾病患者的效果及其对肠道菌群和肾间质纤维化的影响  

Effects of sodium ferulate on early diabetic nephropathy, intestinal flora and renal interstitial fibrosis

作　　者：单帅 冯培红 王欢欢 陈忠锋 Shan Shuai;Feng Peihong;Wang Huanhuan;Chen Zhongfeng(Department of Endocrinology,Zhengzhou Central Hospital,Zhengzhou University,Zhengzhou 450000,China;不详)

机构地区：[1]郑州大学附属郑州中心医院内分泌科,450000 [2]郑州大学附属郑州中心医院肾内科,450000

出　　处：《国际移植与血液净化杂志》2023年第3期1-4,共4页International Journal of Transplantation and Hemopurification

摘　　要：目的探究阿魏酸钠治疗早期糖尿病肾病患者的效果及其对肾间质纤维化和肠道菌群的影响。方法采用掷硬币法将2021年5月至2022年12月于郑州大学附属郑州中心医院就诊的93例早期糖尿病肾病患者分为2组,对照组46例患者接受血糖、血脂、血压强化控制以及优质蛋白饮食等常规治疗,研究组47例患者在前述治疗的基础上加用阿魏酸钠静脉滴注。对比两组患者治疗1个月后肠道菌群、肾间质纤维化和尿微量白蛋白变化以及不良反应发生率。结果治疗后研究组患者革兰氏阳性杆菌(G+b)、革兰氏阴性杆菌(G-b)水平高于对照组,球菌/杆菌比值(c/b)低于对照组(P<0.05),Ⅲ型前胶原(PCⅢ)、Ⅳ型胶原(CⅣ)、结缔组织生长因子(CTGF)、血管紧张素Ⅱ(AngⅡ)、尿微量白蛋白(UmAlb)、β2-微球蛋白(β2-MG)、尿素氮(BUN)和血肌酐(SCr)水平均较对照组低(P<0.05)。两组患者头晕、呕吐、便秘等不良反应发生率以及革兰氏阳性球菌(G+c)、革兰氏阴性球菌(G-c)水平差异无统计学意义(P>0.05)。结论早期糖尿病肾病常规基础治疗的同时加用阿魏酸钠,可有效调节患者肠道菌群分布,同时改善尿微量白蛋白、肾间质纤维化情况,且不增加不良反应。Objective To investigate the effect of sodium ferulate on renal interstitial fibrosis and intestinal flora in patients with early diabetic nephropathy.Methods Ninety-three patients with early diabetic nephropathy in Zhengzhou Central Hospital Affiliated to Zhengzhou University from May 2021 to December 2022 were divided into two groups by coin toss.Forty-Six patients in the control group received intensive control of blood glucose,blood lipids and blood pressure as well as high-quality protein diet and other routine treatment.Forty-seven patients in the study group were treated with sodium ferulate intravenous injection on the basis of routine treatment.Intestinal flora,renal interstitial fibrosis,urinary microprotein changes and adverse reactions at the end of treatment of 1 month were compared between the two groups.Results At the end of treatment of 1 month,the levels of Gram-positive bacilli(G+b)and Gram-negative bacilli(G-b)in the study group were higher than those in the control group,and the levels of cocci/bacilli(c/b)were lower than those in the control group(P<0.05).The levels of typeⅢprecollagen(PCⅢ),typeⅣcollagen(CⅣ),connective tissue growth factor(CTGF)and angiotensinⅡ(AngⅡ),urinary microalbumin(UmAlb),β2-microglobulin(β2-MG),urea nitrogen(BUN)and blood mydomy(SCr)were lower than those in the control group(P<0.05).There were no significant differences in the occurrence of adverse reactions such as dizziness,vomitting,constipation and the levels of Gram positive cocci(G+c)and Gram negative cocci(G-c)between the two groups(P>0.05).Conclusion The routine basic treatment of early diabetic nephropathy combined with sodium ferulate can effectively regulate the distribution of intestinal flora,reduce urinary microproteins and renal interstitial fibrosis,and do not increase adverse reactions.

关 键 词：糖尿病肾病 阿魏酸钠 肠道菌群 尿微量白蛋白 肾间质纤维化 

分 类 号：R587.2[医药卫生—内分泌] R692.9[医药卫生—内科学]