戈舍瑞林联合改良腹腔镜术治疗卵巢子宫内膜异位囊肿伴不孕症的效果  

Efficacy of Goserelin Combined with Modified Laparoscopy in the Treatment of Ovarian Endometriosis Cyst with Infertility

作　　者：王义红 张振峰[1] 朱园园 WANG Yihong;ZHANG Zhenfeng;ZHU Yuanyuan(Gynecology Department,the Second Affiliated Hospital of Henan University of Science and Technology,Luoyang 471000,China)

机构地区：[1]河南科技大学第二附属医院妇科,河南洛阳471000

出　　处：《河南医学研究》2023年第19期3566-3569,共4页Henan Medical Research

摘　　要：目的探讨戈舍瑞林联合改良腹腔镜术治疗卵巢子宫内膜异位囊肿伴不孕症的效果,并分析其妊娠结局。方法选取2020年1月至2021年12月在河南科技大学第二附属医院诊治的82例卵巢子宫内膜异位囊肿伴不孕症患者,随机分为对照组(41例)和研究组(41例),对照组接受改良腹腔镜术治疗,研究组接受戈舍瑞林联合改良腹腔镜术治疗,比较两组治疗前后的卵巢功能、疾病相关肿瘤因子,治疗前、治疗1个月、治疗2个月、治疗3个月的数字疼痛评分法(NRS)评分,以及妊娠结局和复发情况。结果治疗后,两组雌二醇(E2)、黄体生成素(LH)、卵泡刺激素(FSH)、窦卵泡计数(AFC)较治疗前均降低(P<0.05),两组抗缪勒氏管激素(AMH)较治疗前均升高(P<0.05),研究组E2、LH、FSH低于对照组(P<0.05),研究组AMH、AFC高于对照组(P<0.05)。治疗后,两组基质细胞衍生因子-1(SDF-1)、趋化因子受体-4(CXCR-4)、人附睾蛋白4(HE4)较治疗前均降低,且研究组低于对照组(P<0.05)。治疗1、2、3个月,两组NRS评分与治疗前比较均降低(P<0.05),且研究组低于对照组(P<0.05)。研究组妊娠率、生育率高于对照组(P<0.05),研究组的复发率低于对照组(P<0.05)。结论戈舍瑞林联合改良腹腔镜术治疗卵巢子宫内膜异位囊肿伴不孕症,可有效改善卵巢功能,降低疾病相关肿瘤因子,减轻术后疼痛,提高妊娠率和生育率,降低复发率。Objective To explore the efficacy of goserelin combined with modified laparoscopy in the treatment of ovarian endometriosis cyst with infertility,and analyze its pregnancy outcomes.Methods A total of 82 patients with ovarian endometriosis cyst and infertility who were diagnosed and treated in the Second Affiliated Hospital of Henan University of Science and Technology from January 2020 to December 2021 were randomly divided into the control group(41 cases)and the study group(41 cases).The control group was treated with modified laparoscopic surgery,while the study group was treated with combination of goserelin and modified peritoneal endoscopy.The ovarian function and disease-related tumor factors before and after treatment,and national reemployment service(NRS)score before treatment,treatment for 1 month,treatment for 2 months,treatment for 3 months,pregnancy outcomes and recurrence were compared between the two groups.Results After treatment,the levels of estradiol(E2),luteinizing hormone(LH)follicle stimulating hormone(FSH)and antral follicle count(AFC)in both groups decreased compared to before treatment(P<0.05).The levels of anti-Müllerian hormone(AMH)in both groups increased compared to before treatment(P<0.05).The levels of E2,LH,and FSH in the study group were lower than those in the control group(P<0.05),while the levels of AMH and AFC in the study group were higher than those in the control group(P<0.05).After treatment,the levels of stromal cellderived factor-1(SDF-1),chemokine receptor-4(CXCR-4)and human epididymal protein-4(HE4)in both groups decreased compared to before treatment,and the study group was lower than the control group(P<0.05).After treatment for 1,2 and 3 months,the NRS scores of both groups decreased compared to before treatment(P<0.05),and the study group was lower than the control group(P<0.05).The pregnancy rate and fertility rate of the study group were higher than the control group(P<0.05).The recurrence rate of the study group was lower than the control group(P<0.05).Conclusio

关 键 词：戈舍瑞林 改良腹腔镜术 卵巢子宫内膜异位囊肿 不孕症 妊娠结局 

分 类 号：R711.7[医药卫生—妇产科学]