基于数据挖掘技术探讨中药治疗输卵管炎性不孕的用药规律  

Medication rule of traditional Chinese medicine in treatment of salpingitis infertility:A study based on data mining techniques

作　　者：孟颖 代函芮 赵薇婷 徐佳[2] 匡继林[2] MENG Ying;DAI Hanrui;ZHAO Weiting;XU Jia;KUANG Jilin(Hunan University of Chinese Medicine,Changsha 410208,Hunan,China;The Second Affiliated Hospital of Hunan University of Chinese Medicine,Changsha 410005,Hunan,China)

机构地区：[1]湖南中医药大学,湖南长沙410208 [2]湖南中医药大学第二附属医院,湖南长沙410005

出　　处：《湖南中医杂志》2023年第8期36-41,共6页Hunan Journal of Traditional Chinese Medicine

基　　金：湖南省自然科学基金项目(2022JJ70108);湖南省中医药科研计划项目(2020011)。

摘　　要：目的:基于数据挖掘法研究中药治疗输卵管炎性不孕(SI)的用药规律,为临床处方用药提供参考。方法:通过检索2013年1月1日至2022年12月31日中国知网(CNKI)、万方数据(WANFANG DATA)、维普中文科技期刊(VIP)等数据库中有关“中药”“输卵管炎性不孕”的文献,利用Excel 2021将中药种类进行分类及频数统计分析,并利用SPSS 25.0、SPSS Modeler 18.0等统计学软件对高频中药进行聚类分析、关联规则分析,最后利用Cytoscape 3.9.1软件构建药物关联网络图。结果:搜集到治疗SI的各种有效中药方剂147首,用药以活血化瘀药为主,如赤芍、当归、丹参等;四气以寒性为主,五味以苦、辛为主,归经以肝、脾经为主;高频药物聚类分析得到6个药物组合、关联规则分析得到15个药物组合;药物关联网络提示关联性最强的中药组合为“三棱-莪术”。结论:SI主要病机为瘀血阻滞、胞脉不通,治疗以活血化瘀通络为主,注意兼顾他证。Objective:To investigate the medication rule of traditional Chinese medicine(TCM)in the treatment of salpingitis infertility(SI)based on data mining techniques.Methods:The databases such as CNKI,WANFANG Data,and VIP were searched for articles on“traditional Chinese medicine”and“salpingitis infertility”published from January 1 st,2013 to December 31 st,2022.Excel 2021 was used to perform the classification of TCM drugs and the statistical analysis of frequency;SPSS 25.0 and SPSS Modeler 18.0 were used to perform cluster analysis and association rule analysis for high-frequency TCM drugs;Cytoscape 3.9.1 was used to construct a drug association network.Results:A total of 147 valid TCM prescriptions were obtained for the treatment of SI,and blood-activating and stasis-resolving drugs were mainly used,such as Radix Paeoniae Rubra,Angelica sinensis,and Salvia miltiorrhiza.Most drugs were cold in nature and had a bitter or pungent taste,and they mainly entered the liver and spleen meridians.The cluster analysis of high-frequency drugs obtained 6 drug combinations,and the association rule analysis obtained 15 drug combinations.The drug association network showed that the TCM drug combination of Rhizoma Sparganii-Curcuma zedoaria had the strongest association.Conclusion:The main pathogenesis of SI is blood stasis and vascular obstruction of uterine collaterals,and activating blood,resolving stasis,and dredging collaterals are the main treatment methods,with consideration of other syndromes.

关 键 词：输卵管炎性不孕 中药 数据挖掘 用药规律 

分 类 号：R271.917.6[医药卫生—中西医结合]