中医药介导AMPK/mTOR信号通路治疗骨质疏松症的研究进展  

Advances in Chinese medicine-mediated AMPK/mTOR signaling pathway for the treatment of osteoporosis

作　　者：张文豪 易林 向文远 热米拉·艾买提 邓迎杰[1] 廖军[1] 梁志权[1] 李雷疆[1] 方锐[1] Zhang Wenhao;Yi Lin;Xiang Wenyuan;Remira·Aimaiti;Deng Yingjie;Liao Jun;Liang Zhiquan;Li Leijiang;Fang Rui(Department of Orthopedics II,Traditional Chinese Medicine Affiliated Hospital of Xinjiang Medical University(Institute of Traditional Chinese Medicine of Xinjiang Uygur Autonomous Region),Urumqi 830099,China)

机构地区：[1]新疆医科大学附属中医医院(新疆维吾尔自治区中医药研究院)骨二科,乌鲁木齐830099

出　　处：《新医学》2023年第10期704-707,共4页Journal of New Medicine

基　　金：新疆维吾尔自治区领军人才项目(2022TSYCLJ0007);新疆维吾尔自治区重大科技项目(2021B03006)。

摘　　要：骨质疏松症(OP)是一种全身性骨骼疾病,是老年人群常见的骨科疾患,较高的发病率、致残致死率、治疗费用等问题给患者家庭带来了较大的影响,丝氨酸/苏氨酸蛋白激酶(AMPK)/雷帕霉素靶蛋白(mTOR)信号通路对细胞的代谢和凋亡有重要意义。中药单体或中药复方能够通过AMPK/mTOR信号通路影响相关因子表达防治OP,但具体机制尚未完全阐明。该文就AMPK/mTOR通路对成骨细胞和破骨细胞的作用以及中医药在其中的调节作用问题进行综述,为下一步的OP防治工作提供新的视角和思路。Osteoporosis(OP)is a systemic bone disease and a common orthopedic disorder in elderly patients.High morbidity,disability and mortality rates and medical cost of OP bring huge burden to the patients and their family.Serine/threonine protein kinase(AMPK)/mammalian target of rapamycin(mTOR)signaling pathway plays a significant role in cell metabolism and apoptosis.Traditional Chinese medicine monomer or compound can prevent and treat OP by regulating the expression levels of related factors through the AMPK/mTOR signaling pathway,whereas the specific mechanism remains elusive.In this article,the effect of AMPK/mTOR signaling pathway upon osteoblasts and osteoclasts,and the regulatory role of traditional Chinese medicine were reviewed,aiming to provide novel perspectives and ideas for prevention and treatment of OP.

关 键 词：骨质疏松症 AMPK/mTOR信号通路 中医药 成骨细胞 破骨细胞 

分 类 号：R259[医药卫生—中西医结合]