细胞外囊泡在衰弱肌少症患者中对线粒体质量控制与炎症的调节效应  

The effect of extracellular vesicles on the regulation of mitochondrial quality control and inflammation in frailty and sarcopenia in older people

作　　者：王凌霄 闫芳[1] 周莉华[1] Wang Lingxiao;Yan Fang;Zhou Lihua(Department of Geriatrics,The Fifth People's Hospital of Chengdu(The Fifth People's Hospital Affiliated to Chengdu University of Chinese Medicine/The Second Clinical Medical College),Chengdu Institute of Geriatric Diseases,Chengdu 611130,China)

机构地区：[1]成都市第五人民医院(成都中医药大学附属第五人民医院/第二临床医学院)老年医学科,成都市老年疾病研究所,成都611130

出　　处：《中华老年医学杂志》2023年第10期1259-1264,共6页Chinese Journal of Geriatrics

基　　金：四川省卫生健康委科研课题(19PJ170);四川省医学会课题(Q19036)。

摘　　要：老年衰弱&肌少症(PF&S)病理机制多样且复杂,从局部肌肉特异性过程(骨骼肌细胞的线粒体质量控制紊乱)到全身系统性变化(慢性炎症)均有涉及,但是目前连接这些机制的重要分子因素研究尚不够充分。近年来的研究表明细胞外囊泡(EVs)在衰老微环境和衰老相关疾病中发挥重要作用。本文综述了在PF&S背景下线粒体质量控制(MQC)紊乱和慢性炎症的特点及其潜在联系,重点关注了EVs在二者相互作用过程的潜在作用,以期为未来研究提供思路。The pathogenesis of frailty and sarcopenia(PF&S)is multifaceted and complex,ranging from local muscle-specific processes(mitochondrial quality control disorders in skeletal muscle cells)to systemic changes(chronic inflammation).However,the important molecular factors linking these mechanisms are not well understood.Recent studies have shown that extracellular vesicles(EVs)play an important role in the aging microenvironment and age-related diseases.This article reviewed the characteristics and potential connections of mitochondrial quality control(MQC)disorders and chronic inflammation in the context of PF&S,focusing on the potential role of EVs in the interaction between the two types of conditions,in order to provide insights for future research.

关 键 词：衰弱 肌少症 细胞外囊泡 外泌体 线粒体功能障碍 

分 类 号：R685[医药卫生—骨科学]