水凝胶保护腹腔开放创面的研究进展  

Advances of hydrogel in early protection of exposed intra-abdominal organs after open abdomen

作　　者：陈灿文 陈康 李泽 蒋运罡 瞿桂文 刘野 李思澄 黄金健 吴秀文 任建安 Chen Canwen;Chen Kang;Li Ze;Jiang Yungang;Qu Guiwen;Liu Ye;Li Sicheng;Huang Jinjian;Wu Xiuwen;Ren Jian'an(Research Institute of General Surgery,Affiliated Jinling Hospital,Medical School of Nanjing University,Nanjing 210002,China)

机构地区：[1]东部战区总医院普通外科、全军普通外科研究所、南京大学医学院附属金陵医院,南京210002

出　　处：《中华胃肠外科杂志》2023年第9期898-902,共5页Chinese Journal of Gastrointestinal Surgery

基　　金：国家自然科学基金(82270595);江苏省重点研发计划(BE2022823);江苏省医学创新中心(CXZX202217)。

摘　　要：腹腔开放创面的保护是创伤外科的重要课题。早期如何促进肠管间肉芽组织填充, 减少肠壁磨损, 从而避免肠空气瘘的发生, 成为腹腔开放后创面保护的关键性技术难题。水凝胶是一种含水量高, 具有优异生物相容性的仿细胞外基质材料, 被广泛应用于医疗卫生领域。本文综述了天然水凝胶生物材料在腹腔开放创面保护中的应用进展, 为后续腹腔开放创面早期保护材料的研制提供参考。The protection of open abdomen(OA)wound is a significant subject in the field of trauma surgery.The key technical challenge in the early stage of OA wound management involves promoting granulation tissue flling between intestinal segments,reducing intestinal wall abrasion,and preventing the development of enteroatmospheric fistulas(EAF).Hydrogels,characterized by their high water content and exceptional biocompatibility,serve as extracellular matrix-mimicking materials,and are extensively employed in various medical and healthcare applications.In this review,we discuss the application of hydrogel developed by natural biomaterials in OA wounds protection,taking into consideration the unique pathophysiological characteristics of the OA wounds.This review aims to provide valuable insights for the development of hydrogel materials for early-stage OA wound protection in future research.

关 键 词：腹腔开放 创面保护 肠空气瘘 仿生腹膜 水凝胶 

分 类 号：R641[医药卫生—外科学]