中医药疗法对儿童哮喘缓解期肺脾气虚证治疗作用Meta分析  

Meta-analysis of the therapeutic effect of Chinese medicine on asthma remission in children with lung-spleen qi deficiency syndrome

作　　者：张孟云 白晓红[2] Zhang Mengyun;Bai Xiaohong(Liaoning University of Traditional Chinese Medicine,Shenyang Liaoning 110847;Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang Liaoning 110033)

机构地区：[1]辽宁中医药大学,辽宁沈阳110847 [2]辽宁中医药大学附属医院,辽宁沈阳110033

出　　处：《山西中医药大学学报》2023年第8期827-832,共6页Journal of Shanxi University of Chinese Medicine

基　　金：沈阳市科技计划项目(19-112-4-008)。

摘　　要：目的:探究中医药疗法对儿童哮喘缓解期肺脾气虚证的疗效。方法:计算机检索中国知网、万方数据知识服务平台、维普中文期刊数据库、中国生物医学文献服务系统、PubMed等数据库中采用中医药治疗儿童哮喘缓解期(肺脾气虚证)随机对照试验(RCT)的文献,检索时间为建库至2022年12月29日,语言不限。运用Corhrane评价法对所纳入文献进行偏倚风险评估,提取内容进行质量评价,采用RevMan 5.4.1软件进行分析。结果:共纳入12篇文献,包含1297例患者。Meta分析结果显示:观察组采用中医药治疗儿童哮喘缓解期(肺脾气虚证)的疗效与对照组比较,总有效率[Z=7.59,OR=3.51,95%CI(2.54,4.85),P<0.00001]、中医证候积分[Z=6.04,MD=-3.07,95%CI(-4.07,-2.08),P<0.00001]、哮喘发作次数[Z=4.73,MD=-0.74,95%CI(-1.04,-1.43),P<0.00001]、肺功能中最高呼气流量(PEF)[Z=1.30,SMD=0.36,95%CI(-0.19,0.92),P=0.19]、第一秒用力呼气容积(FEV1)[Z=4.06,SMD=0.67,95%CI(0.35,1.00),P<0.0001]、用力肺活量(FVC)[Z=3.73,SMD=0.80,95%CI(0.38,1.23),P=0.0002],观察组疗效优于对照组,差异具有统计学意义(P<0.01)。结论:中医药疗法或联合西医常规疗法治疗儿童哮喘缓解期肺脾气虚证临床疗效更加明显,可以显著减少哮喘发作次数,提高儿童生活质量。Objective:To explore the curative effect of Chinese medicine therapy on asthma remission in children with lung-spleen qi deficiency syndrome.Methods:The literature of randomized controlled trial(RCT)on the use of Chinese medicine in the treatment of asthma in remission stage(lung-spleen qi deficiency syndrome)in children was searched by computer from CNKI,Wanfang Data Knowledge Service Platform,Vip Chinese Journal database,China Biomedical Literature Service System,PubMed and other databases.The retrieval time was from the establishment of the database to December 29,2022,and the language was not limited.The Corhrane method was used to assess the risk of bias of the included literature,and the quality of the extracted content was evaluated.RevMan 5.4.1 software was used for analysis.Results:A total of 12 studies involving 1297 patients were included.The effect of Chinese medicine in the treatment of children with asthma in remission(lung-spleen qi deficiency syndrome)was compared between the observation group and the control group.Meta-analysis results showed that the total effective rate was[Z=7.59,OR=3.51,95%CI(2.54,4.85),P<0.00001],TCM syndrome score(Z=6.04,MD=-3.07,95%CI(-4.07,-2.08),P<0.00001),number of asthma attacks(Z=4.73,MD=-0.74,95%CI(-1.04,-1.43),P<0.00001],peak expiratory flow(PEF)[Z=1.30,SMD=0.36,95%CI(-0.19,0.92),P=0.19],forced expiratory volume in one second(FEV1)[Z=4.06,SMD=0.67,95%CI(0.35,1.00),P<0.0001],and forced vital capacity(FVC)[Z=3.73,SMD=0.80,95%CI(0.38,1.23),P=0.0002].The curative effect of the observation group was better than that of the control group,and the difference was statistically significant(P<0.01).Conclusion:Chinese medicine therapy or the combination of Chinese medicine with conventional western medicine therapy is more effective in the treatment of lung-spleen qi deficiency syndrome in children with asthma in remission stage,which can significantly reduce the number of asthma attacks and improve the quality of life of children.

关 键 词：儿童哮喘 哮喘缓解期 肺脾气虚证 中医药 META分析 

分 类 号：R725.6[医药卫生—儿科] R289.54[医药卫生—临床医学] R256.12