动物内寄生虫丝氨酸蛋白酶研究进展  

Advance in Serine Proteases of Animal Endoparasites

作　　者：陈奕君 周璇[1] 谢跃[1] CHEN Yi-jun;ZHOU Xuan;XIE Yue(College of Veterinary Medicine,Sichuan Agricultural University,Chengdu,Sichuan 611130,China)

机构地区：[1]四川农业大学动物医学院,四川成都611130

出　　处：《动物医学进展》2023年第10期80-84,共5页Progress In Veterinary Medicine

基　　金：国家自然科学基金项目(32273028)。

摘　　要：丝氨酸蛋白酶(serine proteases)是一类以丝氨酸为活性中心的蛋白水解酶,参与动物机体的蛋白质代谢、消化、凝血、发育调节和受精等生理过程,具有重要的生物学研究和应用价值。动物内寄生虫丝氨酸蛋白酶参与虫体营养、发育、宿主入侵、免疫反应和抗凝等生物学过程,在寄生虫寄生生活及其宿主相互作用中发挥着重要的作用。鉴于目前动物内寄生虫丝氨酸蛋白酶的相关研究缺乏系统性归纳和总结,拟对动物内寄生虫的丝氨酸蛋白酶研究现状及其在寄生虫-宿主互作中的生物学功能进行概述,以期为寄生虫丝氨酸蛋白酶的进一步研究提供信息参考。Serine proteases are important proteolytic enzymes which use the serine as the active sites and function in various physiological processes including protein metabolism,digestion,blood coagulation,development regulation and fertilization and therefore represent key molecules with significant practical applications.Serine proteases play important roles in endoparasite nutrition,growth and host invasion and immunoregulation as well as anticoagulation during their parasitisms and parasite-host interactions and therefore closely relate to pathogenic mechanisms.Given current advances on serine proteases of animal endoparasites are scattered,and a systematic and comprehensive review is still lacking so far.Therefore,this review aims to review serine proteases identified from animal endoparasites and their possible roles in parasitism and host-parasite interactions.This information should lay a foundation for studying serine proteases in parasites further.

关 键 词：动物内寄生虫 丝氨酸蛋白酶 结构 功能 寄生虫-宿主互作 

分 类 号：S855.9[农业科学—临床兽医学]