吞噬和细胞运动蛋白1在炎性关节病的作用  

Role of engulfment and cell motility 1 in inflammatory joint diseases

作　　者：杨惠丹 程浩[1] 温鸿雁[1] YANG Hui-dan;CHENG Hao;WEN Hong-yan(Department of Rheumatology,Shanxi Medical University Second Affiliated Hospital,Taiyuan 030001,China)

机构地区：[1]山西医科大学第二医院风湿免疫科,太原030001

出　　处：《中华临床免疫和变态反应杂志》2023年第4期369-373,共5页Chinese Journal of Allergy & Clinical Immunology

基　　金：山西省新兴产业领军人才项目(2020-15)。

摘　　要：吞噬和细胞运动蛋白1(ELMO1)是进化保守的一种蛋白,通过与胞质分裂作用因子(DOCK)结合激活Rac影响肌动蛋白细胞骨架的重塑,促进细胞吞噬、迁移和侵袭,其在恶性肿瘤中的临床意义已被证实,但在自身免疫性疾病中的作用尚未被广泛探索。近年来,有研究表明ELMO1调节免疫细胞功能、炎症反应以及破骨细胞活性,参与类风湿关节炎、强直性脊柱炎等炎性关节病的发生发展,本文就相关文献做一综述。Engulfment and cell motility 1(ELMO1)is an evolutionarily conserved protein that activates Rac by binding to cytosolic dividing factor(DOCK)to affect the remodeling of the actin cytoskeleton and promote cell phagocytosis,migration,and invasion.The role of ELMO1 in cancer has been well established,its implication in autoimmune diseases is not widely explored yet.In recent years,some studies have shown that ELMO1 regulates the function of immune cells and the inflammatory response as well as osteoclast activity.ELMO1 participates in the occurrence and development of rheumatoid arthritis,ankylosing spondylitis,and other inflammatory joint diseases.This article reviews the relevant literature.

关 键 词：吞噬和细胞运动蛋白 炎性关节病 免疫细胞 迁移 炎症 

分 类 号：R593.2[医药卫生—内科学]