白细胞介素-36亚家族与特应性疾病的关系  

Relationship between interleukin-36 subfamily and atopic disease

作　　者：谭雯汶 姚煦 宗文凯 TAN Wen-wen;YAO Xu;ZONG Wen-kai(Department of Dermatology,Hospital of Dermatology,Chinese Academy of Medical Sciences&Peking Union Medical College,Nanjing 210042,China;Department of Allergy and Rheumatology,Hospital of Dermatology,Chinese Academy of Medical Sciences&Peking Union Medical College,Nanjing 210042,China)

机构地区：[1]中国医学科学院、北京协和医学院、皮肤病医院皮肤科,南京210042 [2]中国医学科学院、北京协和医学院、皮肤病医院过敏与风湿免疫科,南京210042

出　　处：《中华临床免疫和变态反应杂志》2023年第4期374-378,共5页Chinese Journal of Allergy & Clinical Immunology

基　　金：江苏省社会发展重大项目面上项目(BE2020632);国家自然科学基金面上项目(82073446)。

摘　　要：白细胞介素(IL)-36亚家族是IL-1家族中新发现的一个亚家族,包括3种具有促炎活性的分子:IL-36α、IL-36β和IL-36γ,以及两种拮抗剂:IL-36受体拮抗剂(IL-36Ra)和IL-38。IL-36亚家族中促炎和抗炎成分之间的失衡,可能会导致包括皮肤在内的各种组织慢性炎症的发展。研究表明,在特应性皮炎(AD)、变应性鼻炎(AR)以及哮喘(AS)等特应性疾病中,IL-36亚家族的异常表达,尤其是促炎成分的过度上调与其发病密切相关。本综述概述IL-36亚家族成员的生物学功能和免疫学作用,分析其在皮肤和呼吸道生理及病理中的调节作用,通过全面综述近几年与之相关的研究,深入探讨IL-36亚家族与AD、AR以及AS发病机制的关系以及潜在用途的最新发现,为特应性疾病的治疗新方案提供方向。The interleukin(IL)-36 subfamily,a recently unveiled branch within the IL-1 family,encompasses three pro-inflammatory molecules:IL-36α,IL-36β,and IL-36γ,in addition to two antagonists:IL-36 receptor antagonist(IL-36Ra)and IL-38.The dysregulation between pro-inflammatory and anti-inflammatory constituents within the IL-36 subfamily potentially contributes to the progression of chronic inflammation in diverse tissues,including the skin.Research underscores a notable correlation between aberrant expression of the IL-36 subfamily,particularly the excessive upregulation of pro-inflammatory elements,and the pathogenesis of atopic conditions such as atopic dermatitis(AD),allergic rhinitis(AR),and Asthma(AS).This review offers an encompassing survey of the biological functions and immunological roles of IL-36 subfamily members,dissecting their regulatory impacts in both the physiological and pathological contexts of the skin and respiratory tract.Through a thorough consolidation of recent research,it probes deeply into the intricate interplay between the IL-36 subfamily and the underlying mechanisms triggering the onset of AD,AR,and AS.Furthermore,it investigates the latest breakthroughs concerning potential applications,thereby paving innovative pathways for atopic disease treatments.

关 键 词：白细胞介素-36亚家族 特应性皮炎 变应性鼻炎 哮喘 

分 类 号：R593.1[医药卫生—内科学]