血清中维生素D联合血清HIF-1α、LDH水平与子痫前期、不良妊娠结局相关性研究  

Study on the Correlation between Serum Vitamin D Combined with Serum HIF-1αand LDH Levels and Preeclampsia and Adverse Pregnancy Outcomes

作　　者：陈秀提 吴翠卿 吴惠美 Chen Xiuti;Wu Cuiqing;Wu Huimei(Department of Obstetrics and Gynecology,Guangzhou Zengcheng District Maternal and Child Health Hospital,Guangzhou 511300,Guangdong Province,China)

机构地区：[1]广州市增城区妇幼保健院妇产科,广东广州511300

出　　处：《中外医药研究》2023年第17期136-138,共3页JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH

基　　金：22021年度广州市增城区科技创新资金计划项目(民生科技项目)编号:2021ZCMS01。

摘　　要：目的:研究血清中维生素D联合血清低氧诱导因子-1α(HIF-1α)、乳酸脱氢酶(LDH)水平与子痫前期、不良妊娠结局相关性。方法:选取2022年3月—2023年2月增城区妇幼保健院收治的子痫前期孕妇80例为观察组,根据妊娠结局分为不良妊娠结局组(48例)、妊娠结局良好组(32例);另选取同期健康孕妇100例为对照组。分析血清维生素D联合HIF-1α、LDH水平与子痫前期相关性。结果:观察组血清维生素D水平低于对照组,血清HIF-1α、LDH水平高于对照组,差异有统计学意义(P<0.001);Pearson相关性分析显示,血清维生素D与子痫前期发病呈负相关(r=-2.325,P<0.001),血清HIF-1α、LDH与子痫前期发病呈正相关(r=0.981、0.721,P=0.007、0.012);不良妊娠结局组血清HIF-1α、LDH水平高于妊娠结局良好组,差异有统计学意义(P<0.001);Pearson相关性分析显示,血清HIF-1α、LDH与不良妊娠结局呈正相关(r=1.047、1.136,P<0.001、P=0.008)。结论:临床中可通过监测血清中维生素D、血清HIF-1α、LDH指标水平变化及时为子痫前期孕妇提供干预治疗,提高围产期的母婴安全,减轻医疗负担。Objective:To study the correlation between serum vitamin D combined with serum hypoxia-inducible factor-1α(HIF-1α)and lactate dehydrogenase(LDH)levels and preeclampsia and adverse pregnancy outcomes.Methods:80 pregnant women with preeclampsia admitted to Guangzhou Zengcheng District Maternal and Child Health Hospital from March 2022 to February 2023 were selected as the observation group.According to the pregnancy outcome,they were divided into adverse pregnancy outcome group(48 cases)and good pregnancy outcome group(32 cases).Another 100 healthy pregnant women during the same period were selected as the control group.Analyze the correlation between serum vitamin D,HIF-1α,LDH levels and preeclampsia.Results:The serum vitamin D level of the observation group was lower than that of the control group,and the serum HIF-1α and LDH levels were higher than those of the control group;The differences were statistically significant(P<0.001);Pearson correlation analysis showed that serum vitamin D was negatively correlated with the onset of preeclampsia(r=-2.325,P<0.001);Serum HIF-1α and LDH were positively correlated with the onset of preeclampsia(r=0.981,0.721,P=0.007,0.012);The serum HIF-1α and LDH levels in the adverse pregnancy outcome group were higher than those in the good pregnancy outcome group,and the difference was statistically significant(P<0.001);Pearson correlation analysis showed that serum HIF-1α,LDH were positively correlated with adverse pregnancy outcomes(r=1.047,1.136,P<0.001,P=0.008).Conclusion:In clinical practice,timely intervention and treatment can be provided for pregnant women with preeclampsia by monitoring changes in serum vitamin D,serum HIF-1α,and LDH index levels,thereby improving maternal and infant safety during the perinatal period and reducing the medical burden.

关 键 词：不良妊娠结局 子痫前期 健康孕妇 医疗负担 维生素D 观察组 母婴安全 妇幼保健院 

分 类 号：R71[医药卫生—妇产科学]