一种含吗啉修饰的多吡啶钯(Ⅱ)配合物的合成、表征与抗金黄色葡萄球菌作用研究  

Synthesis of Polypyridyl Palladium(Ⅱ)Complexes Modified with Morpholine Group and Its Antibacterial Activity Anti-Staphylococcus Aureus

作　　者：王润宾 韩天植 李知敏 尧智玲 廖向文 王金涛 WANG Runbin;HAN Tianzhi;LI Zhimin;YAO Zhiling;LIAO Xiangwen;WANG Jintao(School of Pharmacy,Jiangxi Science&Technology Normal University,Nanchang 330013,China)

机构地区：[1]江西科技师范大学药学院,南昌330013

出　　处：《人工晶体学报》2023年第10期1842-1849,共8页Journal of Synthetic Crystals

基　　金：国家自然科学基金(22067007,22067006);江西科技师范大学大学生创新训练计划(20211504111)。

摘　　要：由4′-[4-(4-吗啉基丁氧基)苯基]-2,2′∶6′,2″-三联吡啶合成了一种含吗啉修饰的三联吡啶钯配合物(Pd1),并通过核磁氢谱、元素分析和X射线单晶衍射对其结构进行表征。Pd1对金黄色葡萄球菌(S.aureus)表现出良好的抗菌活性(MIC=62.48μg/mL,MIC为最小抑菌浓度)。通过耐药实验发现金黄色葡萄球菌对Pd1不易产生耐药性,筛选发现Pd1与盐酸克林霉素联合作用时,可以增强金黄色葡萄球菌对盐酸克林霉素的敏感性。机制研究发现Pd1对与产生耐药性有关的生物膜有明显的抑制作用。此外,Pd1对金黄色葡萄球菌产生的毒素活性具有明显的抑制作用。One Polypyridyl Pd(Ⅱ)complex(Pd1)containing modified morpholine group was synthesized from 4’-[4-(4-morpholinobutyloxy)phenyl]-2,2’∶6’,2’-tripyridine and characterized by 1 H NMR,element analysis and single crystal X-ray diffraction.The antibacterial activity of Pd1 was investigated against S.aureus with the MIC(minimum inhibition concentration)value of 62.48μg/mL and the effect of Pd1 complex on S.aureus growth was investigated by growth curves.Bacteria resistance development assay indicate that the S.aureus cannot easily develop drug-resistance to Pd1.In addition,Pd1 complex can strengthen the susceptibility of S.aureus to clidamycin hydrochloride when it is combined with clidamycin hydrochloride.Meanwhile,Pd1 has a significant inhibitory effect on biofilms related to drug resistance,and show obviously inhibitory activity against the toxins from S.aureus.

关 键 词：金属配合物 多吡啶钯配合物 吗啉 晶体结构 抗金黄色葡萄球菌 联合作用 

分 类 号：O641[理学—物理化学]