3-甲基吡啶悬臂Cu(Ⅱ)-Zn(Ⅱ)异双核配合物的合成、晶体结构及其与CT-DNA的结合活性  

Synthesis,Crystal Structure,and CT-DNA Binding Activity of a 3-Methylpyridyl Pendant-Arms Cu(II)-Zn(II)Hetero-Binuclear Complex

作　　者：王洋 李铭[2] 关金涛 张智勇 闫俊涛 熊兰[2] 毛佳伟[2] WANG Yang;LI Ming;GUAN Jintao;ZHANG Zhiyong;YAN Juntao;XIONG Lan;MAO Jiawei(School of Chemical and Environmental Engineering,Wuhan Polytechnic University,Wuhan 430023,China;Sichuan Institute of Product Quality Supervision and Inspection,Chengdu 610100,China)

机构地区：[1]武汉轻工大学化学与环境工程学院,武汉430023 [2]四川省产品质量监督检验检测院,成都610100

出　　处：《人工晶体学报》2023年第10期1858-1866,共9页Journal of Synthetic Crystals

基　　金：Science and Technology of the State Administration of Market Regulation(2022MK111);Sichuan Natural Science Foundation(2023NSFSC1805)。

摘　　要：本文通过3,3′-((乙基-1,2-二基双((吡啶-2-甲基)杂氮二基))双亚甲基)二(2-羟基-5-甲基苯甲醛)(H2L)和丙二胺在金属离子存在条件下的缩合反应,得到了一个新型3-甲基吡啶悬臂Cu(Ⅱ)-Zn(Ⅱ)异双核配合物,并通过红外光谱、紫外光谱、电喷雾质谱、X射线单晶衍射等手段对其结构进行了表征。单晶衍射结果表明该配合物属于六方晶系,P63/m空间群,a=1.982 18(17) nm,b=1.982 18(17) nm,c=1.839 4(2) nm,分子式为C37H41CuN6O4Zn。金属中心Cu(Ⅱ)和Zn(Ⅱ)由两个酚氧原子和一个醋酸根桥联,它们的配位环境都可以近似地看作为四方锥结构,Cu(Ⅱ)和Zn(Ⅱ)之间的距离是0.289 7 nm。本文还利用循环伏安实验和黏度实验的方法对该配合物与小牛胸腺DNA(CT-DNA)的相互作用模式进行了研究,结果表明该配合物与CT-DNA的结合方式为弱的插入模式,其相应的结合活性为6.92×103mol/L。A new 3-methylpyridyl pendant-arms Cu(Ⅱ)-Zn(Ⅱ)hetero-binuclear complex was synthesized by condensation reaction of 3,3′-((ethane-1,2-diylbis((pyridin-2-ylmethyl)azanediyl))bis(methylene))bis(2-hydroxy-5-methylbenzaldehyde)(H_(2)L)and propane diamine in the presence of metal ions.The structure was characterized by IR spectroscopy,UV-Vis spectroscopy,ES-MS spectroscopy and X-ray single-crystal diffraction.The crystal structure reveals that the complex crystallizes in hexagonal,space group P6_(3)/m,with a=1.98218(17)nm,b=1.98218(17)nm and c=1.8394(2)nm.The coordination environment of Zn(Ⅱ)and Cu(Ⅱ)in complex can be described as approximately square pyramid,where the apical positions are occupied by acetate radical.Two metal centers are equivalently bridged by the phenolic oxygens and an acetate radical with the intermetallic separation of 0.2897 nm.The interaction between the complex and calf thymus DNA(CT-DNA)was measured by cyclic voltammetry and viscosity studies,which shows a weak binding activity of 6.92×10^(3) mol/L.

关 键 词：3-甲基吡啶悬臂 Cu(Ⅱ)-Zn(Ⅱ)异双核配合物 单晶衍射 配位环境 CT-DNA结合 

分 类 号：O641.4[理学—物理化学]