藏族中老年人群不同类型肥胖与高同型半胱氨酸血症的关联研究  

Study on the relationship between different types of obesity and hyperhomocysteinemia in middle-aged and elderly Tibetans

作　　者：索朗曲珍 黄倩 李亚杰[1] 白国霞[1] SUOLANG Qu-zhen;HUANG Qian;LI Ya-jie;BAI Guo-xia(Center for Disease Control and Prevention of Tibet Autonomous Region,Lhasa,Tibet 850000,China;不详)

机构地区：[1]西藏自治区疾病预防控制中心,西藏拉萨850000 [2]四川大学华西公共卫生学院/华西第四医院,四川成都610041

出　　处：《现代预防医学》2023年第19期3636-3640,共5页Modern Preventive Medicine

摘　　要：目的 研究西藏农牧区中老年人群高同型半胱氨酸血症患病率及其与不同类型肥胖的关联。方法 分层整群抽样的方法抽取拉萨市三个县/区40岁以上常住人群作为调查对象。采用条件logistic回归模型分析不同类型肥胖与高同型半胱氨酸血症(HHcy)的关联。结果 纳入分析的数据共2 951例,西藏农牧区居民高同型半胱氨酸血症(HHcy)患病率为67.6%,高同型半胱氨酸血症(HHcy)者中男性、较高年龄、收入水平低、水果食用频率低者所占比例较高。以正常体重+非中心型肥胖组作为参照组,一般型肥胖+中心型肥胖者患HHcy的风险增加55%,OR和95%CI为1.55(1.16~2.08),一般型肥胖+非中心型肥胖者患HHcy的风险增加51%,OR和95%CI为1.51 (1.17~1.96),超重+中心型肥胖者患HHcy的风险增加48%,OR和95%CI为1.48 (1.14~1.92)。结论 西藏农牧区居民高同型半胱氨酸血症(HHcy)患病率高,同时患有一般型肥胖和中心型肥胖者患HHcy的风险更高。Objective To investigate the prevalence of hyperhomocysteinemia (HHcy) its association with different types of obesity in middle-aged and elderly people in agricultural and pastoral areas of Tibet. Methods By using the method of stratified cluster sampling, the permanent residents over 40 years old in three counties/districts of Lhasa were selected as the survey subjects. Conditional logistic regression model was used to analyze the relationship between different types of obesity and hyperhomocysteinemia. Results A total of 2 951 cases were included in the analysis, and the prevalence rate of HHcy in agricultural and pastoral areas of Tibet was 67.6%. Participants of men,older-age,lower income level and frequency of fruit consumption were more likely to have HHcy. Taking the normal weight + non-central obesity group as the reference group, the general obesity + central obesity group increased the risk of HHcy by 55% (OR=1.55, 95%CI: 1.16-2.08) and 51% (OR=1.51, 95%CI: 1.17-1.96), respectively, and those who were overweight and central obesity had a 48% increased risk of HHcy (OR=1.48, 95%CI: 1.14-1.92), respectively. Conclusion The prevalence of HHcy is high among residents in agricultural and pastoral areas of Tibet, and those who suffer from both general obesity and central obesity have a higher risk of HHcy.

关 键 词：一般型肥胖 中心型肥胖 高同型半胱氨酸血症 

分 类 号：R589[医药卫生—内分泌]