原发性肾病综合征患者中医证型与病理类型、血清免疫球蛋白和肾功能的关系分析  

Relationship between TCM sy ndromes and pathological types,serum immunoglobulins.renal function in patients with Primary Nephrotic Syndrome

作　　者：张士奇[1] 袁良东[1] 刘青 ZHANG Shiqi;YUAN Liang-dong;LU Qing(Deparment of Nephrology,Affiliated Hospinl of Jining Medical College,Jining Shandong 272100,China)

机构地区：[1]济宁医学院附属医院肾内科,山东济宁272100

出　　处：《四川中医》2023年第6期79-81,共3页Journal of Sichuan of Traditional Chinese Medicine

摘　　要：目的:分析原发性肾病综合征(NS)患者中医证型与病理类型、血清免疫球蛋白和肾功能的关系。方法:选择2020年4月~2022年4月在本院就诊的146例原发性NS患者为研究对象。将所有患者根据中医辨证标准分为脾肾阳虚证、肺肾气虚证、气阴两虚证、肝肾阴虚证,比较不同中医证型患者病理类型、免疫球蛋白及肾功能。结果:146例NS患者的证型以脾肾阳虚证为主,其余证型肺肾气虚证、气阴两虚证、肝肾阴虚证分别占比为24.66%、12.33%、9.59%。不同中医证型患者病理类型比较,多组间差异无统计学意义(P>0.05);不同中医证型患者免疫球蛋白水平比较,多组间差异无统计学意义(P>0.05);不同中医证型患者肾功能比较,多组间血肌酐和血尿素氨水平比较无统计学意义(P>0.05),尿酸水平比较有统计学意义(P<0.05),且肺肾气虚证组尿酸水平低于脾肾阳虚证组(P<0.05)。结论:原发性NS患者中医证型与病理类型、血清免疫球蛋白无关联,但与肾功能有关,其中,脾肾阳虚证患者和肺肾气虚证患者比较,肾功能损伤程度更重。Objective:To analyze the relationship between TCM syndromes and pathological types,serum immunoglobulins,renal function in patients with primary nephrotic syndrome(NS).Methods:A total of 146patients with primary NS treated in the hospital were enrolled as the research objects between April 2020and April 2022.According to different TCM syndromes,they were divided into spleen-kidney yang deficiency syndrome,syndrome of insufficiency of lung and kidney qi,syndrome of defi-ciency of both vital Qi and Yin,deficiency syndrome of both liver and kidney yin.The pathological types,immunoglobulins and renal function in patients with different TCM syndromes were compared.Results:In the 146patients with primary NS,main TCM syndrome was spleen-kidney yang deficiency syndrome,followed by syndrome of insufficiency of lung and kidney qi,syndrome of deficiency of both vital Qi and Yin,syndrome of insufficiency of lung and kidney qi,(24.66%,12.33%,9.59%).There was no significant difference in pathological types or immunoglobulins among different TCM syndromes(P>0.05).There was no significant difference in levels of serum creatinine and blood urea ammonia among different TCM syndromes(P>0.05),but there were signifi-cant differences in level of uric acid(P<0.05).The level of uric acid in syndrome of insufficiency of lung and kidney qi group was lower than that in spleen-kidney yang deficiency syndrome group(P<0.05).Conclusion:TCM syndromes are not related to patho-logical types or serum immunoglobulins,but related to renal function in patients with primary NS.Compared with syndrome of insuf-ficiency of lung and kidney qi,patients with pleen-kidney yang deficiency syndrome has severer renal function injury.

关 键 词：原发性肾病综合征 中医证型 病理类型 血清免疫球蛋白 肾功能 

分 类 号：R692[医药卫生—泌尿科学]