肿瘤乏氧分子探针的研究进展  

Research Progress in Molecular Probes for Tumor Hypoxia

作　　者：陈华 覃君霞 谭必穗 王孜 CHEN Hua;QIN Junxia;TAN Bisui;WANG Zi(School of Chemistry and Pharmaceutical Science,Guangxi Normal University,Guilin,Guangxi,541004,China;Ankang Central Hospital,Ankang,Shaanxi,725000,China)

机构地区：[1]广西师范大学化学与药学学院,广西桂林541004 [2]安康市中心医院,陕西安康725000

出　　处：《广西科学》2023年第4期625-633,共9页Guangxi Sciences

基　　金：国家自然科学基金项目(22167004);广西自然科学基金项目(2023GXNSFFA026014)资助。

摘　　要：近年来,恶性肿瘤严重威胁大众生命健康,给我国社会和医疗带来了沉重的负担,其中乏氧已成为大多数实体瘤的关键特征之一,肿瘤乏氧的发展与其侵袭性和耐药性密切相关,研究其发生发展规律,对恶性肿瘤的早期诊断与筛查具有十分重要的意义。分子探针能对乏氧进行可视化检测,有望实现乏氧肿瘤的准确影像,已成为当前恶性肿瘤诊治的交叉学科前沿之一。本文基于不同生物标志物[硝基还原酶(Nitroreductase, NTR)、偶氮还原酶和氢醌还原酶(Quinone Oxidoreductase, hNQO1)]系统总结了国内外肿瘤乏氧分子探针的研究进展,重点讨论了乏氧分子探针的设计方法、检测机理、传感性能和生物应用,并对肿瘤乏氧分子探针的未来发展趋势进行了展望。In recent years,malignant tumors have seriously threatened the lives and health of the public and brought a heavy burden to our society and medical care.Hypoxia has become one of the key characteristics of most solid tumors.The development of tumor hypoxia is closely related to its invasiveness and drug resistance.Studying its occurrence and development law is of great significance for the early diagnosis and screening of malignant tumors.The molecular probe can visually detect hypoxia and is expected to achieve accurate imaging of hypoxic tumors,which has become one of the frontiers of cross-disciplines in the diagnosis and treatment of malignant tumors.Based on different biomarkers[Nitroreductase(NTR),azoreductase and Quinone Oxidoreductase(hNQO1)],this article systematically summarizes the research progress of tumor hypoxia molecular probes at home and abroad.The design method,detection mechanism,sensing performance and biological application of hypoxic molecular probes are emphatically discussed.The future development trend of tumor hypoxia molecular probes is prospected.

关 键 词：肿瘤 乏氧 分子探针 硝基还原酶 偶氮还原酶 氢醌还原酶 

分 类 号：O657.3[理学—分析化学]