用于CARS成像的波长可调谐光纤激光器  

Wavelength tunable fiber laser for CARS imaging

作　　者：赵明泽 李佳颖 刘亮[1] 李典典 郝强[1] 杨康文 ZHAO Ming-Ze;LI Jia-Ying;LIU Liang;LI Dian-Dian;HAO Qiang;YANG Kang-Wen(School of Optical Electrical and Computer Engineering,University of Shanghai for Science and Technology,Shanghai 200093)

机构地区：[1]上海理工大学光电信息与计算机工程学院,上海200093

出　　处：《红外与毫米波学报》2023年第5期681-686,共6页Journal of Infrared and Millimeter Waves

基　　金：国家自然科学基金(11974248,62175064)。

摘　　要：相干反斯托克斯拉曼散射(CARS)显微成像在快速病理学分析、药代动力学等领域展现了极大的应用潜力,然而在成像时产生的非共振背景噪声信号会影响CARS信号的探测。通过调谐波长,可实现在拉曼共振、非共振噪声共存处产生信号,也可实现在仅有非共振噪声处产生信号,两信号相消可以在一定程度上消除非共振背景噪声的影响。文章搭建了基于分离脉冲放大及晶体倍频的波长可调谐掺铒光纤激光系统,通过控制两级放大器的泵浦功率实现了779.1~784.5 nm,777.5~786.1 nm,784.5~790.5 nm的波长调谐,获得了110.8 mW,136 fs的脉冲输出。通过与掺镱激光系统被动同步,可用于CARS成像。Coherent anti-Stokes Raman scattering(CARS)microscopy showed great potential for rapid pathological analysis,pharmacokinetics and other fields.However,the non-resonant background(NRB)signals generated during imaging will affect the detection of CARS signals.By tuning the wavelength,the signal can be generated at the coexistence of resonance and NRB,or at the place where there is only NRB.The influence of NRB can be eliminated to a certain extent by cancelling the two signals.In this paper,a wavelength tunable erbium-doped fiber laser system based on divided pulse amplifier and crystal frequency doubling was built.It was proposed to control the pump power of two-stage amplifiers to achieve wavelength tuning.Finally,110.8 mW and 136 fs pulses were output at 779.1-784.5 nm,777.5-786.1 nm and 784.5-790.5 nm.The laser and ytterbium-doped laser system can be used for CARS imaging through passive synchronization.

关 键 词：相干反斯托克斯拉曼散射 波长可调谐 非共振背景噪声 

分 类 号：O437[机械工程—光学工程]