宣肺化痰汤辅助治疗小儿细菌性肺炎痰热闭肺证55例临床观察  

Clinical observation on 55 cases of pediatric bacterial pneumonia with phlegm-heat obstructing lung syndrome adjuvantly treated by Xuanfei Huatan Tang(宣肺化痰汤)

作　　者：陈银丽 CHEN Yinli(Department of Pediatrics,Yuyao Maternity and Child Health Care Hospital,Yuyao,Zhejiang,315400,China)

机构地区：[1]余姚市妇幼保健院儿科,浙江余姚315400

出　　处：《中医儿科杂志》2023年第5期49-53,共5页Journal of Pediatrics of Traditional Chinese Medicine

摘　　要：目的 观察宣肺化痰汤辅助治疗小儿细菌性肺炎痰热闭肺证的临床疗效。方法 选取2019年1月至2021年12月余姚市妇幼保健院儿科收治的细菌性肺炎痰热闭肺证患儿110例,采用随机数字表法分为治疗组和对照组,各55例。对照组予常规对症治疗,包括物理和药物降温、氨溴特罗口服溶液化痰、头孢曲松钠抗感染治疗,治疗组在对照组治疗方法的基础上联合宣肺化痰汤治疗。2组均治疗7 d后统计疗效。结果 对照组总有效率为87.27%(48/55),治疗组为98.18%(54/55),2组比较,差异有统计学意义(P<0.05)。治疗组退热时间、止咳时间、肺部湿啰音消失时间均早于对照组,2组比较,差异有统计学意义(P<0.05)。2组治疗前中医证候积分比较,差异无统计学意义(P>0.05),具有可比性;治疗后2组中医证候积分均明显降低,与同组治疗前比较,差异有统计学意义(P<0.05),且治疗组降低更显著(P<0.05)。2组治疗前血清炎症因子C-反应蛋白(CRP)、白细胞介素-6(IL-6)、白细胞介素-8(IL-8)及肿瘤坏死因子-α(TNF-α)水平比较,差异无统计学意义(P>0.05),具有可比性;2组治疗后上述血清炎症因子水平均显著降低,与同组治疗前比较,差异有统计学意义(P<0.05),且治疗组降低更显著(P<0.05)。结论 宣肺化痰汤辅助治疗小儿细菌性肺炎痰热闭肺证效果显著,能明显缓解患儿临床症状、体征,缩短病程,有效下调血清炎症因子水平,值得临床推广应用。Objective To observe the clinical efficacy of Xuanfei Huatan Tang(宣肺化痰汤) in adjuvant treatment of children's bacterial pneumonia with phlegm-heat obstructing lung syndrome.Methods From January 2019 to December 2021,110 cases of bacterial pneumonia in children with phlegm-heat obstructing lung syndrome were selected from the pediatric department of Yuyao Maternity and Child Health Care Hospital.They were divided into a treatment group and a control group,with 55 cases in each group.The control group was given routine symptomatic treatment,including physical and drug cooling,ambroxol oral solution expectorant,and ceftriaxone sodium anti infection treatment.The treatment group was treated with Xuanfei Huatan Tang on the basis of the treatment method of the control group.After 7 days of treatment,both groups were statistically analyzed for efficacy.Results The total effective rate of the control group was 87.27%(48/55),while that of the treatment group was 98.18%(54/55).The difference between the two groups was statistically significant(P<0.05).The time for fever relief,cough relief,and lung rale disappearance in the treatment group were all earlier than those in the control group.The difference between the two groups was statistically significant(P<0.05).The comparison of TCM syndrome scores between the two groups before treatment showed no statistically significant difference(P<0.05),indicating comparability.After treatment,both groups of traditional Chinese medicine syndrome scores significantly decreased,and compared with the same group before treatment,the difference was statistically significant(P<0.05),besides,the decrease in the treatment group was more significant(P<0.05).Before treatment,serum levels of inflammatory factor C-reactive protein(CRP),interleukin 6(IL-6),interleukin 8(IL-8) and tumor necrosis factor-α(TNF-α) in two groups compared horizontally,the difference was not statistically significant(P<0.05),indicating comparability;The levels of serum CRP,IL-6,IL-8,TNF-α after treatment in

关 键 词：小儿 细菌性肺炎 痰热闭肺证 宣肺化痰汤 临床观察 

分 类 号：R256.11[医药卫生—中医内科学]