骨靶向药物递送系统研究进展  

Research Progress of Bone-Targeting Drug Delivery System

作　　者：张铭笑 孙春萌 ZHANG Mingxiao;SUN Chunmeng(NMPA Key Laboratory for Research and Evaluation of Pharmaceutical Preparations and Excipients,Center for Research Development and Evaluation of Pharmaceutical Excipients and Generic Drugs,Department of Pharmaceutics,School of Pharmacy,China Pharmaceutical University,Nanjing 210009,China)

机构地区：[1]中国药科大学药学院药剂系,中国药科大学药用辅料及仿创药物研发评价中心,国家药品监督管理局药物制剂及辅料研究与评价重点实验室,江苏南京210009

出　　处：《药学进展》2023年第8期637-640,I0003-I0006,共8页Progress in Pharmaceutical Sciences

摘　　要：骨骼是人体重要的组成部分,随着人口老龄化以及肿瘤高发,骨相关疾病已经严重影响患者的生活质量。全身给药治疗骨类相关疾病存在靶向性差、副作用大、药物利用度低等缺点。骨靶向递药系统有效克服了传统给药方式治疗骨类相关疾病的缺陷,利用骨靶向基团对药物载体进行功能化修饰可有效提高药物疗效,降低成本,并减少不良反应。综述通过查阅相关文献,对近几年骨靶向系统的研究进展进行了归纳总结,介绍了骨靶向系统中骨靶向基团与纳米载体的应用,为骨靶向药物递送系统的深入研究开拓了新的思路。Bone is an important part of the human body.With the aging of the population and the high incidence of tumors,bone-related diseases have seriously affected the quality of life for patients.Systemic drug administration in the treatment of bone diseases has such disadvantages as poor targeting,serious side-effects and low drug utilization.Bone-targeting drug delivery system effectively overcomes the defects of traditional drug delivery methods in the treatment of bone-related diseases using bone-targeting seekers to functionalize drug carriers,thus improving drug efficacy,reducing costs and reducing the occurrence of adverse reactions.In this paper,the research progress of bone-targeting systems in recent years is summarized with reference to relevant literature,and the application of bone-targeting seekers and nanocarriers in bone-targeting system is reviewed,which provides new ideas for the in-depth study of bone-targeting drug delivery system.

关 键 词：骨靶向药物递送系统 骨靶向基团 骨靶向纳米载体 

分 类 号：R944[医药卫生—药剂学]