基于数据挖掘探讨中药坐浴治疗慢性非细菌性前列腺炎的用药规律  

Medication rule of traditional Chinese medicine sitz bath in treatment of chronic nonbacterial prostatitis:A study based on data mining

作　　者：王丽[1] 赵瑞成 朱伟 WANG Li;ZHAO Ruicheng;ZHU Wei(Hunan University of Chinese Medicine,Changsha 410208,Hunan,China;Hunan Hospital of Integrated Traditional Chinese and Western Medicine,Changsha 410006,Hunan,China)

机构地区：[1]湖南中医药大学,湖南长沙410208 [2]湖南省中西医结合医院,湖南长沙410006

出　　处：《湖南中医杂志》2023年第9期40-44,共5页Hunan Journal of Traditional Chinese Medicine

基　　金：湖南省卫生健康委员会重点项目(C202304057972);湖南省自然科学基金面上项目(2022JJ30360);湖南省中医药科研计划重点项目(C2022006);湖南省中医药研究院科研重点项目(201904)。

摘　　要：目的:基于数据挖掘技术探讨中药坐浴治疗慢性非细菌性前列腺炎(CNP)的用药规律,为中医药治疗CNP提供参考。方法:检索自建库至2022年12月7日中国知网(CNKI)、万方数据(WANFANG DATA)、维普中文科技期刊数据库(VIP)、中国生物医学文献服务系统(SinoMed)、PubMed中有关中药坐浴治疗CNP的临床研究文献,建立处方数据库,采用SPSS Modeler 18.0 Apriori算法进行关联规则分析并绘制高频中药共现网络图;采用SPSS Statistics 25.0对中药进行层次聚类分析并绘制树状图。结果:共纳入文献129篇,提取中药处方148首,涉及中药201味,累计使用频次1414次,其中高频中药共20味,排前5位的依次为黄柏、丹参、大黄、败酱草、蒲公英;药性以寒为主,药味以苦为主,多归肝、心、胃经;在中药配伍方面,丹参-黄柏支持度最高;高频中药可分为7个聚类群。结论:中药坐浴治疗CNP以清热利湿、活血化瘀为主,兼顾益气扶正,体现了中医扶正祛邪、标本兼顾的治疗原则。Objective:To investigate the medication rule of traditional Chinese medicine(TCM)sitz bath in the treatment of chronic nonbacterial prostatitis(CNP)based on data mining,and to provide a reference for the TCM treatment of CNP.Methods:CNKI,Wanfang Data,VIP,SinoMed,and PubMed were searched for clinical research articles in TCM sitz bath in the treatment of CNP published up to December 7,2022,and a database was established for the prescriptions.SPSS Modeler 18.0 Apriori algorithm was used to perform association rule analysis and plot the co-occurrence network of high-frequency TCM drugs,and SPSS Statistics 25.0 was used to perform a hierarchical cluster analysis of TCM drugs and plot a tree diagram.Results:A total of 129 articles were included,from which 148 TCM prescriptions were extracted,involving 201 TCM drugs,with a cumulative frequency of use of 1414 times.There were 20 high-frequency drugs,and the top 5 drugs were Phellodendri Chinensis Cortex,Salvia miltiorrhiza,Rheum officinale,Herba Patriniae,and dandelion.Most drugs were cold in nature and had a bitter taste,and they mainly entered the liver,heart,and stomach meridians.As for the compatibility of TCM drugs,the highest degree of support was observed in Salvia miltiorrhiza-Phellodendri Chinensis Cortex.The high-frequency drugs could be clustered into 7 groups.Conclusion:In the treatment of CNP,TCM sitz bath mainly applies the heat-clearing and diuresis-promoting therapy and the blood-activating and stasis-resolving therapy,with consideration to the method of tonifying Qi and strengthening vital Qi,which reflects the TCM treatment principles of strengthening vital Qi,eliminating pathogen,and addressing both the symptoms and root causes.

关 键 词：慢性非细菌性前列腺炎 中药坐浴 用药规律 数据挖掘 

分 类 号：R277.573.3[医药卫生—中医学]