某医院患者感染肺炎链球菌的分布和耐药特征研究  

Analysis of distribution and resistance characteristics of Streptococcus pneumoniae in hospitalized patients

作　　者：王社梁[1] 童海江[1] 沈芳[1] 章金丽 林秀琴 WANG She-liang;TONG Hai-jiang;SHEN Fang;ZHANG Jin-li;LIN Xiu-qin(Shaoxing Second Hospital,Shaoxing Zhejiang 312000;Shaoxing Seventh People's Hospital,China)

机构地区：[1]绍兴第二医院,浙江绍兴312000 [2]绍兴市第七人民医院

出　　处：《中国消毒学杂志》2023年第9期687-690,共4页Chinese Journal of Disinfection

基　　金：浙江省中医药科技计划项目(2021ZB309);浙江省医药卫生科技计划项目(2023KY1271)。

摘　　要：目的了解医院患者感染肺炎链球菌分布和耐药特性,为有效防控提供依据。方法通过病原菌分离鉴定技术和药敏试验方法,对某医院肺炎链球菌感染病例进行调查与分析。结果共调查该医院肺炎链球菌感染患者321例,其中多重耐药菌株占50.47%。肺炎链球菌感染病例中,呼吸道感染占85.67%。临床分离的肺炎链球菌对红霉素和四环素耐药率分别为94.08%和90.03%;对青霉素、阿莫西林、三代头孢菌素和喹诺酮类等抗菌药物比较敏感。多重耐药肺炎链球菌以红霉素+四环素+复方新诺明耐药为主要耐药模式。结论临床分离的肺炎链球菌中多重耐药菌株占50%以上,其对红霉素和四环素耐药性高,对阿莫西林和青霉素等抗菌药物比较敏感。Objective To understand the distribution and drug resistance characteristics of Streptococcus pneumoniae in hospitalized patients,so as to provide a basis for effective prevention and control.Methods Using pathogenic bacteria isolation and identification technique and drug susceptibility test method,the cases of Streptococcus pneumoniae infection in a hospital were investigated and analyzed.Results A total of 321 patients with Streptococcus pneumoniae infection in this hospital were investigated,among which multidrug-resistant strains accounted for 50.47%.In the cases of Streptococcus pneumoniae infection,respiratory tract infection accounted for 85.67%.The drug resistance rates of clinically isolated Streptococcus pneumoniae to erythromycin and tetracycline were 94.08%and 90.03%,respectively;they were relatively sensitive to penicillin,amoxicillin,third-generation cephalosporins,and quinolones.The multidrugresistant Streptococcus pneumoniae was mainly resistant to erythromycin,tetracycline and trimoxazole.Conclusion The multidrug-resistant strains account for more than 50%of clinically isolated Streptococcus pneumoniae,which are highly resistant to erythromycin and tetracycline,but are sensitive to antibacterial drugs such as amoxicillin and penicillin.

关 键 词：肺炎链球菌 多重耐药菌株 医院感染 

分 类 号：R378[医药卫生—病原生物学]