柱状水囊前列腺扩开术治疗小体积前列腺增生:一项单中心开放随机对照临床试验  

Transurethral columnar balloon dilation of the prostate for small volume prostatic hyperplasia:a single-center,open,randomized controlled clinical trial

作　　者：何大立 姚振 崔栋 严奉奇 焦勇 付强 HE Dali;YAO Zhen;CUI Dong;YAN Fengqi;JIAO Yong;FU Qiang(Department of Urology,Tangdu Hospital,Air Force Military Medical University,Xi'an 710038,China)

机构地区：[1]空军军医大学唐都医院泌尿外科,陕西西安710038

出　　处：《现代泌尿外科杂志》2023年第10期830-834,共5页Journal of Modern Urology

基　　金：国家自然科学基金项目(No.82002686)。

摘　　要：目的对比经尿道柱状水囊前列腺扩开术(TUCBDP)与传统经尿道前列腺电切术(TURP)治疗小体积前列腺增生的疗效。方法选择空军军医大学唐都医院泌尿外科自2019年1月—2021年1月确诊的96例小体积前列腺增生患者作为研究对象,随机化区组分为观察组和对照组各48例。观察组行TUCBDP治疗,对照组行TURP治疗。随访24个月,比较两组术前及术后24个月的国际前列腺症状评分(IPSS)、生活质量评分(QOL)、勃起功能专项评分(IIEF-EF)、最大尿流率(Qmax)、残余尿量(PVR)、最大逼尿肌压力(MDP),观察两组手术相关并发症及术后新增或加重性功能障碍发生情况。结果两组患者均顺利完成治疗,观察组手术时间、留置导尿时间均短于对照组(P<0.05);两组术后24个月的QOL、IPSS、IIEF-EF评分、Qmax、PVR、MDP均较术前明显改善(P<0.05);观察组术后24个月时IPSS评分低于对照组(P<0.05),IIEF-EF评分、Qmax均高于对照组(P<0.05);观察组手术相关的并发症发生率、新增或加重性功能障碍发生率均明显低于对照组(P<0.05)。结论TUCBDP治疗小体积前列腺增生疗效显著,在改善术后IPSS评分、IIEF-EF评分、Qmax方面比传统TURP更具优势,安全性更高。Objective To compare the efficacy of transurethral columnar balloon dilation of the prostate(TUCBDP)and transurethral resection of prostate(TURP)in the treatment of small volume prostatic hyperplasia.Methods A total of 96 patients with small volume prostatic hyperplasia diagnosed in our hospital during Jan.2019 and Jan.2021 were enrolled and divided into the observation group and control group,with 48 patients in either group.The observation group received TUCBDP while the control group TURP.The International Prostate Symptom score(IPSS),Quality of Life Score(QOL),international index of erectile function-erectile function(IIEF-EF),maximum urinary flow rate(Qmax),postvoid residual urine(PVR)and maximum detrusor pressure(MDP)of the two groups were compared before surgery and 24 months after surgery.The surgery-related complications and occurrence of new or aggravated sexual dysfunction were observed.Results Both groups successfully completed the treatment.The operation time and indwelling catheterization time were shorter in the observation group than in the control group(P<0.05).The scores of QOL,IPSS and IIEF-EF,the levels of Qmax,PVR and MDP of both groups 24 months after surgery were significantly improved compared with those before surgery(P<0.05).The IPSS score of the observation group was lower than that of the control group 24 months after surgery(P<0.05),while the IIEF-EF score and Qmax of the observation group were higher than those of the control group(P<0.05).The incidences of surgery-related complications and new or aggravated sexual dysfunction were significantly lower in the observation group than in the control group(P<0.05).Conclusion TUCBDP is significantly effective in the treatment of small volume prostatic hyperplasia,showing greater advantages than TURP in improving postoperative IPSS,IIEF-EF score and Qmax,with higher safety.

关 键 词：小体积前列腺增生 经尿道柱状水囊前列腺扩开术 经尿道前列腺电切术 性功能障碍 

分 类 号：R699.8[医药卫生—泌尿科学]