男性年龄对冻融胚胎移植周期妊娠结局的影响  

Effects of paternal age on pregnancy outcomes in frozen-thaw embryo transfer cycles

作　　者：周桥 季慧[1] 姜薇 张颂 李德红 凌秀凤[1] 陈晓宁[1] ZHOU Qiao;JI Hui;JIANG Wei;ZHANG Song;LI Dehong;LING Xiufeng;CHEN Xiaoning(Center of Reproduction Medicine,Nanjing Maternal and Child Health Care Hospital Affiliated to Nanjing Medical University,Nanjing Maternity and Child Health Care Hospital,Nanjing 210004,China)

机构地区：[1]南京医科大学附属妇产医院(南京市妇幼保健院)生殖医学中心,江苏南京210004

出　　处：《现代泌尿外科杂志》2023年第10期835-837,845,共4页Journal of Modern Urology

基　　金：江苏省自然科学基金(No.BK20220200);南京市卫生科技发展专项基金(No.YKK21158)。

摘　　要：目的观察男性年龄对冻融胚胎移植周期妊娠结局的影响。方法回顾性分析倾向性评分匹配(PSM)后的两组,包括<40周岁组738个周期、40~65周岁组387个周期的临床资料,比较两组一般资料、妊娠结局的差异以及进行两组妊娠结局的条件logistics回归分析。结果两组PSM后的女性年龄、不孕时间、体质量指数(BMI)、不孕因素、受精方式、内膜准备方案、转化日内膜厚度、移植胚胎阶段、移植胚胎数、优质胚胎数均无统计学差异(P>0.05);结果提示:与<40周岁组比较,40~65周岁组男性临床妊娠率(52.2%vs.67.2%)、活产率下降(41.1%vs.57.2%)(P<0.001),两组流产率无统计学差异(19.8%vs.13.7%)(P>0.05)。结论冻融胚胎移植周期中男性高龄可降低临床妊娠率、胎儿活产率。Objective To observe the effects of paternal age on the pregnancy outcomes in frozen embryo transfer(FET)cycles.Methods The clinical data of two groups after propensity score matching(PSM)were retrospectively analyzed,including 738 cycles in the<40 year group and 387 cycles in the 40-60 year group.The differences in general information and pregnancy outcomes were compared between the two groups,and logistic regression analysis of pregnancy outcomes were conducted.Results There were no statistical differences in age,duration of infertility,female body mass index(BMI),infertility factors,fertilization method,endometrial preparation methods,endometrial thickness on the day of transformation,stage of embryo transfer,number of embryos transferred,and number of high-quality embryos between the two groups after PSM(P>0.05).The clinical pregnancy rate(52.2%vs.67.2%)and live birth rate(41.1%vs.57.2%)decreased in the 40-60 year group compared with those in the<40 year group(P<0.001),but there was no statistical difference in abortion rate(19.8%vs.13.7%)(P>0.05).Conclusion Advanced paternal age decreases clinical pregnancy rate and live birth rate.

关 键 词：男性高龄 冻融胚胎移植 临床妊娠率 活产率 

分 类 号：R715[医药卫生—妇产科学]