Brugada波心电机制的新认识  

New understandings about electrocardiographic mechanism of Brugada wave

作　　者：李韩 钟国强[2] LI Han;ZHONG Guoqiang(Department of Cardiology,Liuzhou People’s Hospital,Liuzhou Guangxi 545006;Clinical Medical College,the First Affiliated Hospital of Guangxi Medical University,Guilin Guangxi 530021,China)

机构地区：[1]柳州市人民医院心内科,广西柳州545006 [2]广西医科大学第一附属医院临床医学院,广西桂林530021

出　　处：《实用心电学杂志》2023年第5期360-364,共5页Journal of Practical Electrocardiology

摘　　要：Brugada波是一种特殊的心电图形,表现为右束支阻滞、右胸导联ST段抬高和T波倒置“三联征”,可导致心律失常和心脏性猝死。既往认为Brugada波与遗传学、电生理学、神经崤假说等有关。最新研究发现线粒体DNA、tRNA突变,炎症,心肌基质异常可能也参与了Brugada波的发生发展。本文主要从Brugada波的心电机制最新研究进展方面进行综述。Brugada wave is a special ECG pattern that presents as a“triad”of right bundle branch block,STsegment elevation in the right chest lead,and T wave inversion.It could lead to arrhythmia and sudden cardiac death.It has been previously considered that Brugada wave is associated with genetics,electrophysiological mechanism,nerve crest hypothesis and so on.The latest studies have found that mutations in mitochondrial DNA and tRNA,inflammation,and myocardial stroma abnormalities may also be involved in the occurrence and development of Brugada wave.This paper mainly reviews the latest research progress of the electrocardiographic mechanism of Brugada wave.

关 键 词：BRUGADA波 心律失常 电风暴 药物治疗 奎尼丁 异丙肾上腺素 

分 类 号：R540.41[医药卫生—心血管疾病]