Effects of dynamic flow rates on degradation deposition behavior of Mg scaffold  

作　　者：Gaozhi Jia Meng Zhou Yicong Huang Chenxin Chen Liang Jin Qian Wu Jian Weng Fei Yu Ao Xiong Guangyin Yuan Frank Feyerabend Hui Zeng 

机构地区：[1]Department of Bone&Joint Surgery,Peking University Shenzhen Hospital,Shenzhen Peking University-The Hong Kong University of Science and Technology Medical Center,Shenzhen Institute of Information Technology,Shenzhen 518036,China [2]National Engineering Research Center of Light Alloy Net Forming&State Key Laboratory of Metal Matrix Composite,Shanghai Jiao Tong University,Shanghai 200240,China [3]Beijing Key Laboratory of Civil Aircraft Structures and Composite Materials,Beijing Aircraft Technology Research Institute of COMAC,Beijing 102211,China [4]College of Life Science,Zhejiang Chinese Medical University,Hangzhou 310053,China [5]Shenzhen Branch,Guangdong Laboratory of Lingnan Modern Agriculture,Genome Analysis Laboratory of the Ministry of Agriculture and Rural Affairs,Agricultural Genomics Institute at Shenzhen,Chinese Academy of Agricultural Sciences,Shenzhen 518120,China [6]Department of Orthopaedics,Peking University People’s Hospital,Beijing 100044,China [7]Division of Metallic Biomaterials,Institute of Materials Research,Helmholtz-Zentrum Hereon,Geesthacht 21502,Germany [8]National&Local Joint Engineering Research Center of Orthopaedic Biomaterials,Peking University Shenzhen Hospital,Shenzhen 518036,China

出　　处：《Journal of Magnesium and Alloys》2023年第6期2054-2060,共7页镁合金学报（英文）

基　　金：supported by grants from National&Local Joint Engineering Research Center of Orthopaedic Biomaterials(XMHT20190204007);Shenzhen Key Medical Discipline Construction Fund(No.SZXK023);Shenzhen“San-Ming”Project of Medicine(No.SZSM201612092);Shenzhen Research and Development Project(No.Z2021N054);Guangdong Basic and Applied Basic Research Foundations(No.2019A1515011290,2021A1515012586,2019A1515110983);China Postdoctoral Science Foundation(No.2020M672756);Bethune Charitable Foundation and CSPC Osteoporosis Research Project(No.G-X-2020–1107–21)。

摘　　要：Degradability of bone tissue engineering scaffold that matching the regeneration rate could allow a complete replacement of host tissue.However,the porous structure of biodegradable Mg scaffolds certainly generated high specific surface area,and the three-dimensional interconnected pores provided fast pervasive invasion entrance for the corrosive medium,rising concern of the structural integrity during the degradation.To clarify the structural evolution of the three-dimensional(3D)porous structure,semi-static immersion tests were carried out to evaluate the degradation performance in our previous study.Nevertheless,dynamic immersion tests mimicking the in vivo circulatory fluid through the interconnected porous structure have yet been investigated.Moreover,the effects of dynamic flow rates on the degradation deposition behavior of 3D porous Mg scaffolds were rarely reported.In this study,Mg scaffolds degraded at three flow rates exhibited different degradation rates and deposition process.A flow rate of 0.5 m L/min introduced maximum drop of porosity by accumulated deposition products.The deposition products provided limited protection against the degradation process at a flow rate of 1.0 m L/min.The three-dimensional interconnected porous structure of Mg scaffold degraded at 2.0 m L/min well retained after 14 days showing the best interconnectivity resistance to the degradation deposition process.The dynamic immersion tests disclosed the reason for the different degradation rates on account of flow rates,which may bring insight into understanding of varied in vivo degradation rates related to implantation sites.

关 键 词：Porous Mg scaffold DEGRADABILITY POROSITY Dynamic immersion test Degradation rate 

分 类 号：TG146.22[一般工业技术—材料科学与工程] R318.08[金属学及工艺—金属材料]