冠状动脉粥样硬化性心脏病合并肺动脉高压患者血清ADMA、IL-6、TGF-β1水平检测意义  

Significance of serum ADMA, IL-6 and TGF-β1 levels in patients with coronary heart disease complicated with pulmonary hypertension

作　　者：王佩佩 吕菲菲 石慧丽 WANG Peipei;LYU Feifei;SHI Huili(Coronary Care Unit,Zhengzhou Central Hospital Affiliated to Zhengzhou University,Zhengzhou,Henan 450000,China)

机构地区：[1]郑州大学附属郑州中心医院CCU,河南郑州450000

出　　处：《中国医学工程》2023年第10期81-85,共5页China Medical Engineering

摘　　要：目的探讨冠状动脉粥样硬化性心脏病(CHD)合并肺动脉高压(PAH)患者血清不对称二甲基精氨酸(ADMA)、白细胞介素6(IL-6)、转化生长因子-β1(TGF-β1)水平,并分析其对CHD合并PAH的诊断价值。方法选取2019年6月至2022年6月郑州大学附属郑州中心医院收治的冠状动脉粥样硬化性心脏病(CHD)患者66例为研究对象,依据是否合并肺动脉高压(PAH)分为单纯CHD组22例、CHD合并PAH组44例,同期选取本院体检的健康志愿者132例为对照组。比较各组临床资料及不同组(入组时)、不同疾病严重程度患者血清ADMA、IL-6、TGF-β1水平。分析血清各指标与疾病严重程度、心肺功能相关性。分析血清各指标对CHD合并PAH的诊断价值。结果血清ADMA、IL-6、TGF-β1水平:CHD合并PAH组>单纯CHD组>对照组,重度>中度>轻度(P<0.05);ADMA、IL-6、TGF-β1与氨基末端B型脑钠肽前体(NT-proBNP)、肌钙蛋白I(cTnI)、肺动脉收缩压(sPAP)、肺动脉舒张压(dPAP)、疾病严重程度呈正相关(P<0.05);联合诊断CHD合并PAH的曲线下面积(AUC)大于单项诊断(P<0.05)。结论CHD合并PAH患者血清ADMA、IL-6、TGF-β1水平升高,且与病情严重程度相关,临床监测其水平变化诊断CHD合并PAH具有一定应用价值。【Objective】To investigate the levels of serum asymmetric dimethylarginine(ADMA),interleukin-6(IL-6)and transforming growth factor-β1(TGF-β1)in patients with coronary heart disease(CHD)combined with pulmonary arterial hypertension(PAH),and to analyse their diagnostic value for CHD combined with PAH.【Methods】A total of 66 patients with coronary heart disease(CHD)admitted to Zhengzhou Central Hospital Affiliated to Zhengzhou University from June 2019 to June 2022 were selected as the study object,and were divided into CHD group(22 cases)and CHD complicated with PAH group(44 cases)according to whether they were complicated with PAH,and 132 healthy volunteers from the hospital were selected as the control group during the same period.The clinical data of the three groups and serum levels of ADMA,IL-6 and TGF-β1 were compared among different groups(at the time of enrollment)and patients with different disease severity.The correlation between serum indexes and disease severity and cardiopulmonary function was analyzed.The diagnostic value of serum indexes for CHD complicated with PAH was analyzed.【Results】Serum levels of ADMA,IL-6 and TGF-β1 were as follows:CHD with PAH group>CHD group>control group,severe>moderate>mild(P<0.05).ADMA,IL-6 and TGF-β1 were positively correlated with amino terminal B-type brain natriuretic peptide precursor(NT-proBNP),troponin I(cTnI),systolic pulmonary artery pressure(sPAP),diastolic pulmonary artery pressure(dPAP)and disease severity(P<0.05).The AUC of CHD combined with PAH was higher than that of single diagnosis(P<0.05).【Conclusion】The serum levels of ADMA,IL-6 and TGF-β1 in patients with CHD complicated with PAH are increased,which is related to the severity of the disease.Clinical monitoring of the changes of their levels in the diagnosis of CHD complicated with PAH has certain application value.

关 键 词：冠状动脉粥样硬化性心脏病 肺动脉高压 不对称二甲基精氨酸 白细胞介素6 转化生长因子-β1 

分 类 号：R541.4[医药卫生—心血管疾病]