血清GGT、TBil、TG与胆囊结石并胆总管结石内镜术后胆总管结石复发的关联性研究  

Correlation between serum GGT,TBil,TG and choledocholithiasis recurrence after endoscopic cholecystolithiasis combined with choledocholithiasis

作　　者：赵晨 李萌[1] 戚润鹏 ZHAO Chen;LI Meng;QI Runpeng(Fifth Clinical Medical College of Henan University of Traditional Chinese Medicine(Zhengzhou People's Hospital),Zhengzhou,Henan 450000,China)

机构地区：[1]河南中医药大学第五临床医学院(郑州人民医院),河南郑州450000

出　　处：《中国医学工程》2023年第10期86-90,共5页China Medical Engineering

摘　　要：目的探讨胆囊结石并胆总管结石内镜术后血清γ-谷氨酰转移酶(GGT)、总胆红素(TBil)、甘油三酯(TG)与胆总管结石复发的相关性,分析其对术后复发的预测价值。方法选取2020年2月至2022年3月于河南中医药大学第五临床医学院(郑州人民医院)行内镜取石术的80例胆囊结石并胆总管结石患者为研究对象,依据术后1年复发情况分为复发组22例、未复发组58例。比较两组基线资料及术前、术后3个月、术后6个月血清GGT、TBil、TG水平。分析血清各指标水平与生化指标相关性,并分析术后3个月、6个月对术后复发的预测价值。比较术后6个月血清各指标不同水平者复发风险。结果术后3个月、6个月两组血清GGT、TBil、TG水平低于术前,且复发组高于未复发组(P<0.05);GGT、TBil、TG与生化指标密切相关(P<0.05);术后3个月、6个月时,联合预测术后复发的曲线下面积(AUC)大于单项预测(P<0.05);GGT、TBil、TG高水平者术后复发危险度分别是低水平的1.685倍、1.743倍、1.608倍(P<0.05)。结论血清GGT、TBil、TG与胆囊结石并胆总管结石内镜术后复发密切相关,联合检测其水平对术后复发具有一定预测价值。【Objective】To investigate the correlation between serum gamma-glutamyl transpeptidyase(GGT),total bilirubin(TBil)and triglyceride(TG)and the recurrence of choledocholithiasis after endoscopic cholecystolithiasis combined with choledocholithiasis,and to analyze their predictive value for postoperative recurrence.【Methods】A total of 80 patients with cholecystolithiasis and choledocholithiasis who underwent endoscopic lithotomy in Fifth Clinical Medical College of Henan University of Traditional Chinese Medicine(Zhengzhou People's Hospital)from February 2020 to March 2022 were selected as research objects,and were divided into a recurrence group of 22 patients and a non-recurrence group of 58 patients according to the recurrence situation one year after surgery.Baseline data and serum GGT,TBil and TG levels before surgery,3 months and 6 months after surgery were compared between the two groups.The correlation between serum indexes and biochemical indexes was analyzed,and the predictive value of postoperative recurrence at 3 months and 6 months was analyzed.The recurrence risk of patients with different levels of serum indexes was compared 6 months after operation.【Results】The serum GGT,TBil and TG levels in 2 groups were lower at 3 months and 6 months after surgery,and the recurrence group was higher than the non-recurrence group(P<0.05).GGT,TBil and TG were closely correlated with biochemical indices(P<0.05).At 3 months and 6 months after surgery,the AUC of postoperative recurrence predicted by combination was greater than that of single prediction(P<0.05).The risk of postoperative recurrence in patients with high GGT,TBil and TG levels was 1.685 times,1.743 times and 1.608 times of those with low GGT,TBIL and TG levels,respectively(P<0.05).【Conclusion】Serum GGT,TBil and TG are closely related to the recurrence of cholecystolithiasis and choledocholithiasis after endoscopic surgery,and the combined detection of their levels has certain predictive value for postoperative recurrence.

关 键 词：胆囊结石 胆总管结石 Γ-谷氨酰转移酶 总胆红素 甘油三酯 

分 类 号：R657.4[医药卫生—外科学]