血清T淋巴细胞亚群水平变化与狼疮性肾炎患者疾病转归的相关性  

Correlation between changes in serum T-lymphocyte subpopulation levels and disease regression in patients with lupus nephritis

作　　者：李飞[1] 常洁[1] 董少卿[1] LI Fei;CHANG Jie;DONG Shaoqing(Department of Nephrology,First Affiliated Hospital of Henan University of Science and Technology,Luoyang,Henan 471003,China)

机构地区：[1]河南科技大学第一附属医院肾内科,河南洛阳471003

出　　处：《中国医学工程》2023年第10期106-110,共5页China Medical Engineering

摘　　要：目的探讨血清T淋巴细胞亚群水平与狼疮性肾炎(LN)患者疾病转归相关性,分析其对疾病转归的预测价值。方法选取2019年1月至2022年3月河南科技大学第一附属医院收治的82例LN患者为研究对象,依据治疗6个月后疾病转归情况分为转归良好组65例、转归不良组17例。分析不同组(治疗前、治疗1个月、3个月后)、不同病情严重程度血清T淋巴细胞亚群水平(CD4^(+)、CD3^(+)、CD16^(+)/CD56^(+)、CD19^(+))。分析T淋巴细胞亚群与生化指标、病情严重程度相关性。分析治疗1个月、3个月后T淋巴细胞亚群水平对疾病转归的预测价值。结果治疗1个月、3个月后转归良好组CD4^(+)、CD3^(+)、CD16^(+)/CD56^(+)高于转归不良组,CD19^(+)低于转归不良组(P<0.05);CD4^(+)、CD3^(+)、CD16^(+)/CD56^(+)与白蛋白、补体C3、补体C4呈正相关,其与尿素氮、病情严重程度呈负相关,而CD19^(+)与之相反(P<0.05);治疗1个月、3个月后各指标联合预测疾病转归的曲线下面积(AUC)大于单项预测(P<0.05)。结论血清T淋巴细胞亚群水平变化与LN患者疾病转归密切相关,联合检测其水平对疾病转归具有一定预测价值。【Objective】To investigate the correlation between serum T lymphocyte subpopulation levels and disease regression in patients with lupus nephritis(LN)and to analyze its predictive value for disease regression.【Methods】Eighty-two patients with LN admitted to First Affiliated Hospital of Henan University of Science and Technology from January 2019 to March 2022 were selected for the study,and were divided into 65 cases in the good regression group and 17 cases in the poor regression group based on disease regression after 6 months of treatment.The levels of serum T lymphocyte subsets(CD4^(+),CD3^(+),CD16^(+)/CD56^(+),CD19^(+))were analyzed in different groups(before treatment,after 1 month and 3 months of treatment)and at different severity of disease.Correlation of T-lymphocyte subsets with biochemical parameters and severity of disease was analyzed.The predictive value of T lymphocyte subpopulation levels on disease regression after 1 month and 3 months of treatment was analyzed.【Results】CD4^(+),CD3^(+),CD16^(+)/CD56^(+)were higher in the group with good regression than in the group with poor regression after 1 month and 3 months of treatment,and CD19^(+)was lower than that in the group with poor regression(P<0.05).CD4^(+),CD3^(+),and CD16^(+)/CD56^(+)were positively correlated with albumin,complement C3,and complement C4,which were negatively correlated with urea nitrogen and severity of disease,while CD19^(+)was the opposite(P<0.05).The AUC of the index combination predicting disease regression after 1 month and 3 months of treatment was greater than the individual predition(P<0.05).【Conclusion】Changes in serum T lymphocyte subpopulation levels are closely related to disease progression in LN patients,and the combined detection of their levels has some predictive value for disease progression.

关 键 词：狼疮性肾炎 T淋巴细胞亚群 疾病转归 相关性 

分 类 号：R593.241[医药卫生—内科学] R692[医药卫生—临床医学]