氯沙坦钾与依那普利治疗高血压合并高尿酸血症的疗效比较  

Efficacy Comparison of Losartan Potassium and Enalapril in the Treatment of Hypertension Complicated with Hyperuricemia

作　　者：洪玲丽 HONG Ling-li(Pharmacy Department of Jinxi County Hospital of Traditional Chinese Medicine,Jinxi 344800,Jiangxi,China)

机构地区：[1]金溪县中医院药剂科,江西金溪344800

出　　处：《医学信息》2023年第20期133-136,共4页Journal of Medical Information

摘　　要：目的比较氯沙坦钾与依那普利治疗高血压合并高尿酸血症(HUA)的临床疗效。方法选取2020年7月-2022年7月金溪县中医院收治的80例高血压并HUA患者,按照随机数字表法分为氯沙坦钾组(40例)与依那普利组(40例),氯沙坦钾组给予氯沙坦钾治疗,依那普利组采用依那普利治疗,比较两组降压疗效、降尿酸疗效、血压水平[收缩压(SBP)、舒张压(DBP)]、血尿酸、炎症因子水平[白介素6(IL-6)、肿瘤坏死因子(TNF-α)]及不良反应。结果两组降压总有效率比较,差异无统计学意义(P>0.05);氯沙坦钾组的降尿酸有效率高于依那普利组(P<0.05);两组治疗后SBP、DBP、血尿酸水平均低于治疗前,且氯沙坦钾组血尿酸水平低于依那普利组(P<0.05),但两组SBP、DBP水平比较,差异无统计学意义(P>0.05);两组治疗后IL-6、TNF-α水平低于治疗前,且氯沙坦钾组IL-6、TNF-α水平低于依那普利组(P<0.05);氯沙坦钾组与依那普利组不良反应发生率比较,差异无统计学意义(P>0.05)。结论氯沙坦钾与依那普利在高血压并HUA治疗中均具有确切疗效,二者降压效果相当,且不良反应相似,但氯沙坦钾的降尿酸作用更优,可促进患者炎症因子水平的进一步下调。Objective To compare the clinical efficacy of losartan potassium and enalapril in the treatment of hypertension complicated with hyperuricemia(HUA).Methods A total of 80 patients with hypertension complicated with HUA admitted to Jinxi County Hospital of Traditional Chinese Medicine from July 2020 to July 2022 were selected and divided into losartan potassium group(40 patients)and enalapril group(40 patients)according to the random number table method.The losartan potassium group was treated with losartan potassium,and the enalapril group was treated with enalapril.The antihypertensive effect,uric acid reduction effect,blood pressure level[systolic blood pressure(SBP),diastolic blood pressure(DBP)],serum uric acid,inflammatory factor levels[interleukin 6(IL-6),tumor necrosis factor(TNF-α)]and adverse reactions were compared between the two groups.Results There was no significant difference in the total effective rate of blood pressure reduction between the two groups(P>0.05).The total effective rate of lowering uric acid in losartan potassium group was higher than that in enalapril group(P<0.05).After treatment,the levels of SBP,DBP and serum uric acid in the two groups were lower than those before treatment,and the level of serum uric acid in the losartan potassium group was lower than that in the enalapril group(P<0.05),but there was no significant difference in the levels of SBP and DBP between the two groups(P>0.05).After treatment,the levels of IL-6 and TNF-αin the two groups were lower than those before treatment,and the levels of IL-6 and TNF-αin the losartan potassium group were lower than those in the enalapril group(P<0.05).There was no significant difference in the incidence of adverse reactions between losartan potassium group and enalapril group(P>0.05).Conclusion Losartan potassium and enalapril have definite curative effects in the treatment of hypertension complicated with HUA.The antihypertensive effects of the two are similar,and the adverse reactions are similar.However,losartan potassium ha

关 键 词：高血压 高尿酸血症 氯沙坦钾 依那普利 收缩压 舒张压 血尿酸 

分 类 号：R544.1[医药卫生—心血管疾病] R589[医药卫生—内科学]