常见溶瘤病毒在结直肠癌动物实验中的研究现状  

Research status of common oncolytic viruses in animal experiments of colorectal cancer

作　　者：王璐 王杰[2,3] 陈腾[2,3] 殷佩浩[2,3] WANG Lu;WANG Jie;CHEN Teng;YIN Pei-hao(School of Medicine and Life Sciences,Chengdu University of Traditional Chinese Medicine,Chengdu 611137,Sichuan Province,China;Departmenttof General Surgery,Putuo Hospital Affiliated to Shanghai University of traditional Chinese Medicine,Shanghai 200062,China;Shanghai Putuo Center Clinical College,Anhui Medical University,Shanghai 200062,China)

机构地区：[1]成都中医药大学医学与生命科学学院,四川成都611137 [2]上海中医药大学附属普陀医院普外科,上海200062 [3]安徽医科大学上海普陀中心临床学院,上海200062

出　　处：《中国临床药理学杂志》2023年第17期2571-2575,共5页The Chinese Journal of Clinical Pharmacology

基　　金：国家科技部重点研发计划基金资助项目(2019YFC1316003);国家自然科学基金面上基金资助项目(81973625);上海市普陀区卫生健康系统临床特色专病建设基金资助项目(2019tszb01)。

摘　　要：结直肠癌是最常见的恶性肿瘤之一,手术、化疗和放疗等传统治疗方法虽然已取得一定进展,但是治疗效果有限,且肿瘤复发、耐药和死亡率较高的问题仍然存在,因此需要开发更加有效的治疗方法和药物。溶瘤病毒疗法是肿瘤治疗的新兴方法,其在选择性复制并杀死肿瘤细胞的同时,还能改善肿瘤免疫抑制微环境,诱导抗肿瘤免疫反应,是一种重要的免疫联合疗法。本文综述了溶瘤病毒的作用机制、常见的几类溶瘤病毒在结直肠癌中动物实验的应用研究以及增强溶瘤病毒疗法效果的手段,以期待将来能更安全、更有效、更广泛地将溶瘤病毒应用于结直肠癌的治疗。Colorectal cancer is one of the most common malignant tumors.Although some progress has been made in traditional treatments such as surgery,chemotherapy and radiotherapy,the effect is not good,and the problems of high tumor recurrence,drug resistance and mortality still exist,so it is necessary to develop more effective treatments and drugs.Oncolytic virus therapy is a new method of tumor therapy.It can not only selectively replicate and kill tumor cells,but also improve tumor immunosuppressive micro-environment and induce anti-tumor immune response.This article reviews the mechanism of oncolytic virus,the application of several common oncolytic viruses in animal experiments in colorectal cancer,and the methods to enhance the effect of oncolytic virus therapy,in order to make the use of oncolytic virus more safely,effectively and widely in the treatment of colorectal cancer in the future.

关 键 词：溶瘤病毒 结直肠癌 作用机制 动物研究 

分 类 号：R97[医药卫生—药品]