基于DTI-ALPS方法评估类淋巴系统功能的研究进展  

Research progress in the evaluation of glymphatic system function by the DTI-ALPS method

作　　者：王淞 孙善億 刘慧[3] 黄清[1,2,4] WANG Song;SUN Shanyi;LIU Hui;HUANG Qing(Department of Neurology,Xiangya Hospital,Central South University,Changsha 410008;Hunan Clinical Research Center for Cerebrovascular Diseases,Changsha 410008;Department of Radiology,Xiangya Hospital,Central South University,Changsha 410008;National Clinical Research Center for Geriatric Disorders,Xiangya Hospital,Changsha 410008,China)

机构地区：[1]中南大学湘雅医院神经内科,长沙410008 [2]湖南省脑血管病临床医学研究中心,长沙410008 [3]中南大学湘雅医院放射科,长沙410008 [4]国家老年疾病临床医学研究中心(湘雅医院),长沙410008

出　　处：《中南大学学报（医学版）》2023年第8期1260-1266,共7页Journal of Central South University ：Medical Science

基　　金：湖南省自然科学基金(2022JJ30930);国家老年疾病临床医学研究中心基金(2021KFJJ04)。

摘　　要：类淋巴系统可以清除脑内代谢废物,对维持中枢神经系统的内环境稳态起着重要作用,是学习、记忆等高级认知功能的重要基础。近来,越来越多的研究采用沿血管周围间隙弥散张量成像分析(diffusion tensor imaging analysis along the perivascular space,DTI-ALPS)方法评估类淋巴功能。相比其他需要荧光示踪技术或注射造影剂的有创检查,DTI-ALPS可以通过量化不同方向上水分子的弥散率对类淋巴系统进行流体力学评估,是一种无创的在体神经影像学方法。利用DTI-ALPS方法计算出的ALPS指数与中枢神经系统疾病及其他系统疾病的认知功能显著相关,并能反映疾病的动态变化。因此,ALPS指数有望成为预测疾病预后及临床干预疗效的新型神经影像学生物标志物。The glymphatic system can remove metabolic wastes from the brain,which plays a significant role in maintaining the homeostasis of the central nervous system.It is an important basis for advanced cognitive functions such as learning and memory.Studies have analyzed the function of glymphatic system by diffusion tensor imaging analysis along the perivascular space(DTI-ALPS)recently.Compared with other invasive examinations that require fluorescent tracer technique or the injection of contrast agents,DTI-ALPS can evaluate the hydromechanics of the glymphatic system via quantifying the diffusion rate of water molecules in different directions,which turns out to be a non-invasive in vivo neuroimaging method.The ALPS-index calculated by the DTI-ALPS method is significantly correlated with the cognitive function in diseases of central nervous system and other system and can reflect the dynamic changes of diseases.In general,ALPS-index is expected to become a novel neuroimaging biomarker for predicting prognosis and clinical effects.

关 键 词：类淋巴系统 沿血管周围间隙弥散张量成像分析 认知功能障碍 神经影像学生物标志物 

分 类 号：R551.2[医药卫生—血液循环系统疾病]