吡喃鎓衍生物N2的体外抗真菌活性研究  

Investigation on the antifungal activity of pyranium derivatives N2

作　　者：邓忠宇 郭士槿 郭熠凡 冯峻程 吕权真 邱丽娟 DENG Zhongyu;GUO Shijin;GUO Yifan;FENG Juncheng;LV Quanzhen;QIU Lijuan(Basic Medicine School,Naval Medical University,Shanghai 200433,China;School of Pharmacy,Naval Medical University,Shanghai 200433,China)

机构地区：[1]海军军医大学基础医学院,上海200433 [2]海军军医大学药学系,上海200433

出　　处：《药学实践与服务》2023年第10期610-615,共6页Journal of Pharmaceutical Practice and Service

基　　金：海军军医大学大学生创新能力培养基金。

摘　　要：目的研究N2系列化合物的抗真菌作用。方法利用微量液基稀释法考察化合物N2系列化合物的体外抗真菌活性;在菌丝和被膜诱导条件下考察N2化合物对白念珠菌菌丝和被膜形成的抑制效果。结果N2化合物对临床常见条件致病真菌白念珠菌有明显抗真菌活性;N2化合物可以明显抑制白念珠菌菌丝生长和被膜的形成;N2化合物可以通过损伤白念珠菌细胞膜和细胞壁发挥杀菌作用。结论N2化合物具有较为广泛的抗真菌谱,能起到明显的体外抗真菌效果,对真菌菌丝和生物被膜的形成均有明显的抑制作用,可以认为N2化合物具有抗真菌潜力,可作为先导化合物,指导进一步改造。筛选获得了具有抗真菌活性的N2化合物,为抗真菌药物研发和解决真菌耐药问题提供新思路。Objective To study the antifungal activity of N2 derivatives.Methods The anti-fungal activity of N2 compounds was investigated by micro-liquid dilution.Then the activity of N2 compounds on hyphal and biofilm formation was investigated.Results N2 compounds had significant antifungal activity against Candida albicans.It also expressed actively inhibitory effect on hyphal and biofilm formation.The mechanism of its fungicidal function was to damage the structure of candida albicans’cell membrane and cell wall.Conclusion The results showed that N2 had obvious antifungal activity against Candida albicans.,which provided a new idea for the development of antifungal drugs and the solution of antifungal drugs resistance.

关 键 词：N2化合物 抗真菌活性 白念珠菌 菌丝形成 

分 类 号：R978.5[医药卫生—药品]