拓展供肝来源的临床实践与若干思考  

The clinical practice and consideration for donor liver expansion

作　　者：汪恺 高逢强 徐骁[1] Wang Kai;Gao Fengqiang;Xu Xiao(Zhejiang University School of Medicine,Institute of Organ Transplantation of Zhejiang University,Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province,Hangzhou 310058,China)

机构地区：[1]浙江大学医学院、浙江大学器官移植研究所、浙江省肿瘤融合研究与智能医学重点实验室,杭州310058

出　　处：《中华外科杂志》2023年第10期826-832,共7页Chinese Journal of Surgery

基　　金：国家重点研发计划(2021YFA1100500);浙江省“尖兵”“领雁”研发攻关计划(2022C03108)。

摘　　要：肝移植是终末期肝病最有效的治疗手段, 但我国器官供需不平衡问题突出, 如何有效拓展供肝来源是目前移植界的主要研究方向。作者团队综合国内外循证医学证据、前沿学术成果及临床经验, 基于生物-医学-工程交叉融合的新视域, 从边缘性供肝多渠道拓展、移植外科技术多维度创新及异种器官替代多元化探索等方面, 系统阐述了目前供肝池拓展的主要策略, 以期推动大队列构建、大数据融合及高质量的前沿研究, 实现理论创新和临床转化, 促进我国肝移植事业高质量发展。Liver transplantation is the most effective method to address end-stage liver disease.However,there is a huge imbalance between organ supply and demand in China.Recently,effective expansion of the donor liver has become a hot research direction in academia.Authors′group comprehensively integrates domestic and foreign evidence-based medical evidence,the latest academic outcomes and clinical experience.Based on the innovative viewshed of crossfusion between biomedical engineering and medicine,author group systematically elaborate in the main strategies for expanding the liver donor pool,including the multichannel expansion of marginal donor liver,multidimensional innovation of technologies in transplant surgery and diversified exploration of alternative resources of organs.The author group aims to promote the construction of a large cohort,the integration of big data,and the output of high quality research,achieving innovative theory and clinical translation in organ transplantation,thus promoting the higher quality development of liver transplantation in China.

关 键 词：肝移植 供者选择 器官短缺 供肝池 边缘性供肝 异种器官移植 干细胞 

分 类 号：R657.3[医药卫生—外科学]