3D-printed strontium-incorporatedβ-TCP bioceramic triply periodic minimal surface scaffolds with simultaneous high porosity,enhanced strength,and excellent bioactivity  

作　　者：Yanbo Shan Yang Bai Shuo Yang Qing Zhou Gang Wang Biao Zhu Yiwen Zhou Wencan Fang Ning Wen Rujie He Lisheng Zhao 

机构地区：[1]Chinese PLA Medical School,Beijing 100853,China [2]Institute of Stomatology&Oral Maxilla Facial Key Laboratory,First Medical Center of Chinese PLA General Hospital,Beijing 100853,China [3]Institute of Advanced Structure Technology,Beijing Institute of Technology,Beijing 100081,China

出　　处：《Journal of Advanced Ceramics》2023年第9期1671-1684,共14页先进陶瓷（英文）

基　　金：supported by the National Natural Science Foundation of China(Nos.51972339 and 51802350).

摘　　要：In bone tissue engineering,scaffolds with excellent mechanical and bioactive properties play prominent roles in space maintaining and bone regeneration,attracting increasingly interests in clinical practice.In this study,strontium-incorporatedβ-tricalcium phosphate(β-TCP),named Sr-TCP,bioceramic triply periodic minimal surface(TPMS)structured scaffolds were successfully fabricated by digital light processing(DLP)-based 3D printing technique,achieving high porosity,enhanced strength,and excellent bioactivity.The Sr-TCP scaffolds were first characterized by element distribution,macrostructure and microstructure,and mechanical properties.Notably,the compressive strength of the scaffolds reached 1.44 MPa with porosity of 80%,bringing a great mechanical breakthrough to porous scaffolds.Furthermore,the Sr-TCP scaffolds also facilitated osteogenic differentiation of mouse osteoblastic cell line(MC3T3-E1)cells in both gene and protein aspects,verified by alkaline phosphatase(ALP)activity and polymerase chain reaction(PCR)assays.Overall,the 3D-printed Sr-TCP bioceramic TPMS structured scaffolds obtained high porosity,boosted strength,and superior bioactivity at the same time,serving as a promising approach for bone regeneration.

关 键 词：STRONTIUM β-tricalcium phosphate(β-TCP) digital light processing(DLP) 3D printing triply periodic minimal surface(TPMS) bone scaffold 

分 类 号：TP391.73[自动化与计算机技术—计算机应用技术] TQ174.759[自动化与计算机技术—计算机科学与技术]