基于数据挖掘技术探讨曹志群教授治疗反流性食管炎用药规律  

Professor Cao Zhiqun's Medication Rules in Treating Reflux Esophagitis:A Study Based on Data Mining

作　　者：李晓彤 战俊邑 李家立[3] 孔维枝 曹志群[4] 康楠[3] LI Xiaotong;ZHAN Junyi;LI Jiali;KONG Weizhi;CAO Zhiqun;KANG Nan(The First Clinical School,Shandong University of Traditional Chinese Medicine,Jinan 250355,China;Graduate School,Shanghai University of Traditional Chinese Medicine,Shanghai 200000,China;Department of Traditional Chinese Medicine,Affiliated Hospital of Jining Medical University,Jining 272007,China;Department of Gastroenterology,Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Jinan 250014,China)

机构地区：[1]山东中医药大学第一临床医学院,山东济南250355 [2]上海中医药大学研究生院,上海200000 [3]济宁医学院附属医院中医科,山东济宁272007 [4]山东中医药大学附属医院消化内一科,山东济南250014

出　　处：《基层中医药》2023年第9期62-69,共8页Basic Traditional Chinese Medicine

基　　金：国家自然科学青年基金项目(81804064);山东省中医药科技重点项目(2021Z039);山东省自然科学博士基金项目(ZR2018BH034);齐鲁卫生与健康领军人才培育工程(鲁卫人字[2020]3号);山东省中医药高层次人才培育项目(鲁卫函[2022]148号)。

摘　　要：目的 利用数据挖掘方法总结曹志群教授治疗反流性食管炎(RE)的用药规律。方法 搜集并整理曹教授2015年2月—2021年12月于山东省中医院门诊治疗RE的处方,对中药的使用频次、功效、性味及证型进行统计分析。将使用频率> 20%的中药进行因子分析、聚类分析、关联规则分析,并绘制药物关联网络图。结果 收集有效处方295份,涉及中药172味,较高频次的有半夏、砂仁、白术、黄连、黄芪等。以补虚药、理气药频率最高;药物性味以温寒、苦辛为主,归经以脾、肝、胃经为主。证型以肝胃不和、中虚气逆为主。因子分析提取到8个公因子,聚类分析得到3首新处方,关联规则主要为半夏、白术、砂仁与其他药物关联度最高。结论 曹教授治疗RE围绕“肝胃之火上逆,火毒湿邪灼蚀”的基本病机,以“疏肝健脾和胃,解毒化湿降火”为治疗原则,用药以半夏、白术、枳壳、黄连为核心。Objective To summarize the medication rules of Professor Cao Zhiqun in treating of reflux esophagitis(RE)by using the data mining method.Methods Professor Cao's prescriptions for treating RE were collected,and the frequency,efficacy,nature and taste,and indicated syndromes of the Chinese medicines in the prescriptions were statistically analyzed.Furthermore,the factor analysis,cluster analysis,and association rule analysis were carried out for the Chinese medicines with the frequency above 20%.Finally,the association network of high-frequency Chinese medicines was established.Results A total of 295 effective prescriptions were collected,involving 172 Chinese medicines,among which Pinelliae Rhizoma,Amomi Fructus,Atractylodis Macrocephalae Rhizoma,Coptidis Rhizoma,and Astragali Radix had high frequency.The frequency of the Chinese medicines for tonifying and regulating qi movement was high.The commonly used Chinese medicines mainly had a warm or cold nature,a bitter and pungent taste,and tropism to spleen,liver,and stomach meridians.The main indicated syndromes were disharmony between liver and stomach and deficiency and qi counterflow in the middle energizer.The factor analysis extracted eight common factors.The cluster analysis revealed three new prescriptions.The association rules mainly existed between Pinelliae Rhizoma,Atractylodis Macrocephalae Rhizoma,Amomi Fructus and other Chinese medicines.Conclusion Focusing on the basic pathogenesis of ascending of liver and stomach fire,fire toxin burning,and dampness pathogen invasion,Professor Cao treats RE following the principle of soothing liver,invigorating spleen,harmonizing stomach,detoxifying,removing dampness,and reducing fire and mainly used Pinelliae Rhizoma,Atractylodis Macrocephalae Rhizoma,Aurantii Fructus,and Coptidis Rhizoma.

关 键 词：反流性食管炎 数据挖掘 用药规律 因子分析 聚类分析 关联规则分析 

分 类 号：R28[医药卫生—中药学]