Activity-Dependent Phosphorylation of CDKL5 at Serine 407 Regulates Synaptogenesis and Plasticity  

作　　者：Mengying Jiang Qiwu Xu Can Yang Dan Li Ji-Wei Liu Yuxian Zhang Yong-Chuan Zhu Zhi-Qi Xiong 

机构地区：[1]Institute of Neuroscience,State Key Laboratory of Neuroscience,CAS Center for Excellence in Brain Science and Intelligence Technology,Chinese Academy of Sciences,Shanghai,200031,China [2]University of Chinese Academy of Sciences,Beijing,100049,China [3]Shanghai Mental Health Center,Shanghai Jiao Tong University School of Medicine,Shanghai,200030,China [4]Shanghai Center for Brain Science and Brain-Inspired Intelligence Technology,Shanghai,201210,China [5]School of Life Science and Technology,ShanghaiTech University,Shanghai,201210,China

出　　处：《Neuroscience Bulletin》2023年第9期1454-1458,共5页神经科学通报(英文版)

基　　金：This work was supported by the Ministry of Science and Technology(2018YFA0801404);the Shanghai Municipal Science and Technology Major Project(2018SHZDZX05).

摘　　要：Dear Editor,The X-linked gene cyclin-dependent kinase-like 5(CDKL5)encodes a serine/threonine kinase that is associated with CDKL5-deficiency disorder(CDD),a severe developmental and epileptic encephalopathy characterized by early-onset seizures,gross developmental delay,and motor disabilities[1].The expression of CDKL5 is highly enriched in the brain and is significantly induced during postnatal development[2].

关 键 词：seizures enriched CDK 

分 类 号：R338[医药卫生—人体生理学]