血清IL-22、CCR5、LXA4在支气管哮喘患儿中的表达及其对病情评估的价值  

Serum IL-22,CCR5 and LXA4 levels in children with bronchial asthma and their values in disease assessment

作　　者：刘美珍 林莉 秦红兵 Liu Meizhen;Lin Li;Qin Hongbing(Department of Pediatrics,Mianyang Maternity&Child Healthcare Hospital,Mianyang 621051,China)

机构地区：[1]绵阳市妇幼保健院儿内科,绵阳621051

出　　处：《国际呼吸杂志》2023年第9期1046-1051,共6页International Journal of Respiration

摘　　要：目的探讨血清白细胞介素22(IL-22)、趋化因子受体5(CCR5)、脂氧素A4(LXA4)在支气管哮喘患儿中的表达及其对病情评估的价值。方法本研究为观察性研究,采用非随机抽样的方法选取2021年7月至2022年7月绵阳市妇幼保健院收治的70例支气管哮喘患儿为研究对象,根据患儿病情分为急性发作组38例和缓解组32例。另选取30名同期体检健康儿童为对照组。比较3组儿童血清IL-22、CCR5、LXA4水平和肺功能指标[第1秒用力呼气容积(FEV1)占预计值百分比(%pred)、用力肺活量(FVC)、FEV1/FVC]。血清IL-22、CCR5、LXA4水平与肺功能指标的相关性分析采用Pearson相关分析。绘制受试者工作特征曲线分析血清IL-22、CCR5、LXA4评估支气管哮喘病情的价值。结果急性发作组、缓解组血清IL-22、CCR5、LXA4水平均高于对照组[(47.34±3.82)ng/L比(27.56±1.34)ng/L、(42.39±2.93)ng/L比(27.56±1.34)ng/L、(36.26±2.88)μg/L比(21.56±1.06)μg/L、(32.39±1.91)μg/L比(21.56±1.06)μg/L、(250.66±21.87)ng/L比(187.60±13.06)ng/L、(219.42±17.96)ng/L比(187.60±13.06)ng/L],且急性发作组血清IL-22、CCR5、LXA4水平均高于缓解组[(47.34±3.82)ng/L比(42.39±2.93)ng/L、(36.26±2.88)μg/L比(32.39±1.91)μg/L、(250.66±21.87)ng/L比(219.42±17.96)ng/L],差异均有统计学意义(均P<0.05)。急性发作组FEV1%pred、FVC、FEV1/FVC均低于缓解组、对照组[(62.08±3.78)%比(85.49±4.29)%、(62.08±3.78)%比(86.04±4.51)%、(1.64±0.07)L比(2.49±0.13)L、(1.64±0.07)L比(2.55±0.17)L、(71.00±1.81)%比(82.41±2.27)%、(71.00±1.81)%比(82.19±2.60)%],差异均有统计学意义(均P<0.05)。Pearson相关分析显示,血清IL-22、CCR5、LXA4水平与FEV1%pred、FVC、FEV1/FVC水平均呈负相关(均P<0.001)。血清IL-22、CCR5、LXA4水平评估支气管哮喘病情的曲线下面积分别为0.877(95%CI:0.790~0.965)、0.877(95%CI:0.794~0.961)、0.882(95%CI:0.803~0.960)。当IL-22的最佳截断值为44.860 ng/L时,敏感度为81.6%,特异度�ObjectiveTo measure serum levels of interleukin-22(IL-22),C-C chemokine receptor type 5(CCR5)and lipoxin A4(LXA4)in children with bronchial asthma,and to explore their values in disease assessment.MethodsIt was an observational study involving 70 children with bronchial asthma admitted to Mianyang Maternity&Child Healthcare Hospital from July 2021 to July 2022 by non-random sampling method.They were divided into acute attack group(38 cases)and remission group(32 cases)according to their conditions.During the same period,30 healthy children receiving physical examination were included in the control group.Serum levels of IL-22,CCR5,and LXA4,as well as pulmonary function indexes,including the percentage of forced expiratory volume in one second(FEV1)to the expected value(%pred),forced vital capacity(FVC),and FEV1/FVC among the three groups were compared.Correlation analysis of serum IL-22,CCR5,and LXA4 levels and pulmonary function indexes was identified by Pearson correlation analysis.The value of serum IL-22,CCR5 and LXA4 in the assessment of bronchial asthma was analyzed by drawing the receiver operating characteristic(ROC)curves.ResultsSerum levels of IL-22([47.34±3.82]ng/L and[42.39±2.93]ng/L vs[27.56±1.34]ng/L),CCR5([36.26±2.88]μg/L and[32.39±1.91]μg/L vs[21.56±1.06]μg/L)and LXA4([250.66±21.87]ng/L and[219.42±17.96]ng/L vs[187.60±13.06]ng/L)in acute attack group and remission group were significantly higher than those in control group(all P<0.05).Moreover,Serum levels of IL-22([47.34±3.82]ng/L vs[42.39±2.93]ng/L),CCR5([36.26±2.88]μg/L vs[32.39±1.91]μg/L)and LXA4([250.66±21.87]ng/L vs[219.42±17.96]ng/L)in acute attack group were significantly higher than those in remission group(all P<0.05).FEV1%pred([62.08±3.78]%vs[85.49±4.29]%and[86.04±4.51]%),FVC([1.64±0.07]L vs[2.49±0.13]L and[2.55±0.17]L),and FEV1/FVC([71.00±1.81]%vs[82.41±2.27]%and[82.19±2.60]%)in acute attack group were significantly lower than those in remission group and control group(all P<0.05).Pearson correlation analys

关 键 词：哮喘 白细胞介素类 脂氧素类 肺活量 儿童 

分 类 号：R725.6[医药卫生—儿科]