儿童尘螨过敏性哮喘的临床特征和外周血细胞分析  

Clinical characteristics of dust mite allergic asthma in children and peripheral blood cell analysis

作　　者：姜荷云 步美玲 范卫华 冯绛楠 苗瑜 王金荣 Jiang Heyun;Bu Meiling;Fan Weihua;Feng Jiangnan;Miao Yu;Wang Jinrong(Department of Pediatric Respiratory,Shandong Provincial Hospital Affiliated to Shandong First Medical University,Jinan 250021,China)

机构地区：[1]山东第一医科大学附属省立医院小儿呼吸综合科,济南250021

出　　处：《国际呼吸杂志》2023年第9期1060-1068,共9页International Journal of Respiration

基　　金：山东省自然科学基金(ZR2022MH254)。

摘　　要：目的分析儿童尘螨过敏性哮喘的临床特征和外周血细胞特点。方法本研究为观察性研究,采用非随机抽样的方法选取2019年6月至2022年6月于山东第一医科大学附属省立医院就诊的2629例支气管哮喘患儿为研究对象。根据血清吸入过敏原特异性免疫球蛋白E和血清总免疫球蛋白E(tIgE)检测结果将患儿分为单一尘螨过敏组420例、尘螨多重过敏组609例、非尘螨过敏组1097例和非过敏组503例。比较4组哮喘患儿的性别、年龄、就诊季节、外周血细胞和tIgE,分析不同年龄段和不同就诊季节4组哮喘患儿外周血细胞和tIgE变化情况,比较单一尘螨过敏组与尘螨多重过敏组哮喘患儿尘螨过敏等级。结果4组哮喘患儿均为男性比例高于女性,4组哮喘患儿性别比较总体差异有统计学意义(χ^(2)=20.48,P<0.001)。4组哮喘患儿年龄比较总体差异有统计学意义(H=175.32,P<0.001),其中单一尘螨过敏组和尘螨多重过敏组患儿年龄均高于非尘螨过敏组和非过敏组(均P<0.05)。4组哮喘患儿就诊季节构成不同(χ^(2)=39.56,P<0.001)。4组哮喘患儿嗜酸性粒细胞(EOS)绝对值比较总体差异有统计学意义(H=323.94,P<0.001),单一尘螨过敏组和尘螨多重过敏组EOS绝对值高于非过敏组和非尘螨过敏组[0.32(0.18,0.52)×10^(9)/L比0.17(0.10,0.28)×10^(9)/L、0.32(0.18,0.52)×10^(9)/L比0.27(0.14,0.47)×10^(9)/L、0.45(0.26,0.65)×10^(9)/L比0.17(0.10,0.28)×10^(9)/L、0.45(0.26,0.65)×10^(9)/L比0.27(0.14,0.47)×10^(9)/L,均P<0.05]。4组哮喘患儿嗜酸性粒细胞/淋巴细胞比值(ELR)比较总体差异有统计学意义(H=345.40,P<0.001),单一尘螨过敏组和尘螨多重过敏组ELR高于非过敏组和非尘螨过敏组[0.09(0.05,0.14)比0.05(0.03,0.07)、0.09(0.05,0.14)比0.07(0.04,0.12)、0.13(0.08,0.19)比0.05(0.03,0.07)、0.13(0.08,0.19)比0.07(0.04,0.12),均P<0.05]。4组哮喘患儿嗜酸性粒细胞/中性粒细胞比值(ENR)比较总体差异有统计学意义(H=1078ObjectiveTo analyze the clinical characteristics of dust mite allergic asthma in children and peripheral blood cell features.MethodsIt was an observational study involving 2629 children with bronchial asthma who visited Shandong Provincial Hospital Affiliated to Shandong First Medical University from June 2019 to June 2022 by non-random sampling.According to the results of serum inhaled allergen special immunoglobulin E test and serum total immunoglobulin E(tIgE)test,recruited children were assigned into dust mite monosensitized group(420 cases),dust mite polysensitized group(609 cases),non-dust mite sensitized group(1097 cases)and non-sensitized group(503 cases).The sex,age,season of consultation,peripheral blood cells,and tIgE in the four groups were compared.Changes in peripheral blood cells and tIgE of the four groups of asthmatic children in different age groups and seasons of consultation were analyzed.Dust mite sensitized grades of the asthmatic children in the dust mite monosensitized group and the dust mite polysensitized group were compared.ResultsThe proportion of boys was higher than that of girls in all four groups of asthmatic children,and a significant difference in the gender was detected among the four groups(χ^(2)=20.48,P<0.001).There was a significant difference in the age of asthmatic children among the four groups(H=175.32,P<0.001),and the age of children in the dust mite monosensitized group and the dust mite polysensitized group was significantly older than that in the non-dust mite sensitized group and the non-sensitized group(all P<0.05).The composition of the season of consultation significantly differed among the four groups of asthmatic children(χ^(2)=39.56,P<0.001).There was a significant difference in the absolute values of eosinophil(EOS)among the four groups of asthmatic children(H=323.94,P<0.001),and the absolute values of EOS in the dust mite monosensitized group and the dust mite polysensitized group were significantly higher than those in the non-sensitized group and the non-

关 键 词：哮喘 尘螨科 免疫球蛋白E 嗜酸性粒细胞 中性粒细胞 淋巴细胞 

分 类 号：R725.6[医药卫生—儿科]