阻塞性睡眠呼吸暂停与常见神经退行性疾病相关研究进展  

Research progress in obstructive sleep apnea and common neurodegenerative diseases

作　　者：林慧 高晓玲[2] Lin Hui;Gao Xiaoling(The Second Clinical Medical College of Shanzi Medical University,Taiyuan 030001,China;Department of Respiratory and Critical Care Medicine,Second Hospital of Shanri Medical University,Taiyuan 030001,China)

机构地区：[1]山西医科大学第二临床医学院,太原030001 [2]山西医科大学第二医院呼吸与危重症医学科,太原原030001

出　　处：《国际呼吸杂志》2023年第9期1109-1112,共4页International Journal of Respiration

基　　金：国家自然科学基金(81870076);山西省留学人员科技活动择优资助项目(20210025)。

摘　　要：目前阻塞性睡眠呼吸暂停(OSA)与神经退行性疾病之间的关系引起越来越多的人重视。大量研究表明,OSA在神经退行性变过程中扮演非常重要的角色,但由于样本量不足、横断面研究的局限性等各种因素,研究的总体情况目前仍不明朗。现有证据表明,OSA针对性治疗可以很大程度延缓神经退行性变的发生发展,有望成为新的疾病修饰疗法。因此,本文将对OSA与常见神经退行性疾病之间的研究进展作一综述。At present,the relationship between obstructive sleep apnea(OSA)and neurodegenerative diseases has attracted more and more attention.A large number of studies have shown that OSA plays an important role in neurodegeneration.However,due to various factors such as insufficient sample size and limitations of cross-sectional studies,the overall situation of the study still remains unclear.Existing evidence indicates that targeted therapy of OSA can significantly delay the occurrence and development of neurodegeneration,and is expected to become a new disease modification therapy.Therefore,this article will review the recent research progress in OSA and common neurodegenerative diseases.

关 键 词：睡眠呼吸暂停 阻塞性 神经变性疾病 阿尔茨海默病 帕金森病 多系统萎缩 

分 类 号：R766[医药卫生—耳鼻咽喉科] R741[医药卫生—临床医学]