阻塞性睡眠呼吸暂停相关肠道菌群紊乱与代谢紊乱关系的研究进展  

Research progress on the relationship between gut microbiota imbalance associated with obstructive sleep apnea and metabolism disorder

作　　者：赵坤 刘爽[1] 许华俊[2] 关建[2] 吴晓林 Zhao Kun;Liu Shuang;Xu Huajun;Guan Jian;Wu Xiaolin(Basic Medical College,Jiamusi University,Jiamusi 154007,China;Department of Otolaryngology,Shanghai Sixth People's Hospital,Shanghai Jiaotong University,School of Medicine,Shanghai 200233,China)

机构地区：[1]佳木斯大学基础医学院,佳木斯154007 [2]上海交通大学医学院上海市第六人民医院耳鼻喉科,上海200233

出　　处：《国际呼吸杂志》2023年第9期1113-1116,共4页International Journal of Respiration

基　　金：国家自然科学基金(82071030、81970870)。

摘　　要：目前多项研究显示阻塞性睡眠呼吸暂停可能导致肠道菌群紊乱。肠道菌群在生物体的生命活动与能量传递中发挥着重要的作用,肠道菌群紊乱有可能造成机体各方面的失衡;并且肠道菌群也是参与代谢的重要成员,肠道菌群紊乱对机体代谢造成了不同程度的影响,与代谢综合征各组分如肥胖、糖尿病、高血压等密切相关。本文从临床研究和不同的动物模型方面综合地阐述了阻塞性睡眠呼吸暂停、肠道菌群紊乱与代谢紊乱之间的关系。Several studies have shown that obstructive sleep apnea may lead to gut microbiota imbalance.Gut microbiota are of significance in mediating life activities and energy transfer,and their imbalance causes imbalances in other systems and organs.Moreover,gut microbiota are important factors involved in metabolism,and their imbalance poses an impact on metabolism at varying degrees.Gut microbiota imbalance is closely linked with metabolic syndromes like obesity,diabetes mellitus and hypertension.This review aims to comprehensively illustrate the correlation of obstructive sleep apnea with gut microbiota imbalance and metabolism disorder in clinical research and in animal models.

关 键 词：睡眠呼吸暂停 阻塞性 代谢综合征 胃肠道微生物组 低氧 高碳酸血症 

分 类 号：R766[医药卫生—耳鼻咽喉科]